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1TFG
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AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2
分子名称: TRANSFORMING GROWTH FACTOR, BETA 2
著者Gruetter, M, Schlunegger, M.
登録日1992-11-17
公開日1993-10-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2.
Nature, 358, 1992
1TGJ
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BU of 1tgj by Molmil
HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE
分子名称: 1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3
著者Mittl, P.R.E, Priestle, J.P, Gruetter, M.G.
登録日1996-07-09
公開日1997-01-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996
2ARV
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BU of 2arv by Molmil
Structure of human Activin A
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, GLYCEROL, Inhibin beta A chain, ...
著者Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M.
登録日2005-08-22
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the inhibition of activin signalling by follistatin
Embo J., 25, 2006
2ASK
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BU of 2ask by Molmil
Structure of human Artemin
分子名称: SULFATE ION, artemin
著者Silvian, L, Jin, P, Carmillo, P, Boriack-Sjodin, P.A, Pelletier, C, Rushe, M, Gong, B.J, Sah, D, Pepinsky, B, Rossomando, A.
登録日2005-08-23
公開日2006-06-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Artemin crystal structure reveals insights into heparan sulfate binding.
Biochemistry, 45, 2006
2BHK
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BU of 2bhk by Molmil
Crystal structure of human growth and differentiation factor 5 (GDF5)
分子名称: GROWTH DIFFERENTIATION FACTOR 5, ISOPROPYL ALCOHOL
著者Schreuder, H, Liesum, A, Pohl, J, Kruse, M, Koyama, M.
登録日2005-01-12
公開日2005-03-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Recombinant Human Growth Differentiation Factor 5. Evidence for Interaction of the Type I and Type II Receptor Binding Sites.
Biochem.Biophys.Res.Commun., 329, 2005
6XM2
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BU of 6xm2 by Molmil
The structure of the 4A11.v7 antibody in complex with human TGFb2
分子名称: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2
著者Lupardus, P.J, Yin, J.P.
登録日2020-06-29
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med, 13, 2021
6Y6O
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BU of 6y6o by Molmil
Structure of mature activin A with small molecule 42
分子名称: (3~{R})-4-ethyl-3-methyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION
著者McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M.
登録日2020-02-26
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Chem Sci, 11, 2020
6Y6N
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BU of 6y6n by Molmil
Structure of mature activin A with small molecule 2
分子名称: (3~{R})-3,4-dimethyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION
著者McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M.
登録日2020-02-26
公開日2021-01-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Chem Sci, 11, 2020
2GYR
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BU of 2gyr by Molmil
Crystal structure of human artemin
分子名称: Neurotrophic factor artemin, isoform 3
著者Wang, X.Q.
登録日2006-05-09
公開日2006-06-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
2GYZ
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BU of 2gyz by Molmil
Crystal structure of human artemin
分子名称: neurotrophic factor artemin isoform 3
著者Wang, X.Q, Garcia, K.C.
登録日2006-05-10
公開日2006-06-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
6SF3
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BU of 6sf3 by Molmil
Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like kinase 1 (ALK1) at 2.3 Angstrom
分子名称: Bone morphogenetic protein 10, Serine/threonine-protein kinase receptor R3
著者Guo, J, Yu, M, Li, W.
登録日2019-07-31
公開日2020-04-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.30000663 Å)
主引用文献Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Nat Commun, 11, 2020
6SF1
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BU of 6sf1 by Molmil
Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1).
分子名称: Bone morphogenetic protein 10, NICKEL (II) ION, Serine/threonine-protein kinase receptor R3
著者Salmon, R.M, Guo, J, Yu, M, Li, W.
登録日2019-07-30
公開日2020-04-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Nat Commun, 11, 2020
5F3H
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BU of 5f3h by Molmil
Structure of myostatin in complex with humanized RK35 antibody
分子名称: Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain
著者Parris, K.D, Mosyak, L.
登録日2015-12-02
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
5F3B
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BU of 5f3b by Molmil
Structure of myostatin in complex with chimeric RK35 antibody
分子名称: GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ...
著者Parris, K.D, Mosyak, L.
登録日2015-12-02
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
1KLA
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BU of 1kla by Molmil
SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 1-17 OF 33 STRUCTURES
分子名称: TRANSFORMING GROWTH FACTOR-BETA 1
著者Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A.
登録日1996-01-16
公開日1996-08-17
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.
Biochemistry, 35, 1996
1KLC
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BU of 1klc by Molmil
SOLUTION STRUCTURE OF TGF-B1, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: TRANSFORMING GROWTH FACTOR-BETA 1
著者Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A.
登録日1996-01-16
公開日1996-08-17
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.
Biochemistry, 35, 1996
1KLD
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BU of 1kld by Molmil
SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 18-33 OF 33 STRUCTURES
分子名称: TRANSFORMING GROWTH FACTOR-BETA 1
著者Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A.
登録日1996-01-16
公開日1996-08-17
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.
Biochemistry, 35, 1996
1LXI
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BU of 1lxi by Molmil
Refinement of BMP7 crystal structure
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BONE MORPHOGENETIC PROTEIN 7
著者Greenwald, J, Groppe, J, Kwiatkowski, W, Choe, S.
登録日2002-06-05
公開日2003-04-01
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly
Mol.Cell, 11, 2003
5I05
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BU of 5i05 by Molmil
Crystal structure of human BMP9 at 1.87 A resolution
分子名称: GLYCEROL, Growth/differentiation factor 2
著者Saito, T, Bokhove, M, Jovine, L.
登録日2016-02-03
公開日2017-06-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Cell Rep, 19, 2017
5TX6
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BU of 5tx6 by Molmil
Structure of TGF-beta2 derivative with deletion of residues 52-71 and 10 single amino acid mutations (mmTGF-beta2-7M)
分子名称: CALCIUM ION, Transforming growth factor beta-2
著者Petrunak, E.M, Hinck, A.P.
登録日2016-11-15
公開日2017-03-01
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (2.746 Å)
主引用文献An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.
J. Biol. Chem., 292, 2017
5TX2
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BU of 5tx2 by Molmil
Miniature TGF-beta2 3-mutant monomer
分子名称: Transforming growth factor beta-2
著者Taylor, A.B, Kim, S.K, Hart, P.J, Hinck, A.P.
登録日2016-11-15
公開日2017-03-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.
J. Biol. Chem., 292, 2017
5UHM
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BU of 5uhm by Molmil
Apo-Structure of Mature Growth Differentiation Factor 11
分子名称: Growth/differentiation factor 11
著者Goebel, E, Thompson, T.
登録日2017-01-11
公開日2017-03-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15, 2017
5VZ3
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BU of 5vz3 by Molmil
Growth Factor Crystal Structure at 1.97 Angstrom Resolution
分子名称: Growth/differentiation factor 15
著者Lakshminarasimhan, D, White, A, Suto, R.K.
登録日2017-05-26
公開日2017-09-27
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
5VT2
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Crystal structure of growth differentiation factor
分子名称: 1,2-ETHANEDIOL, Growth/differentiation factor 15
著者Min, X, Wang, Z.
登録日2017-05-15
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
Sci Transl Med, 9, 2017
2QCQ
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BU of 2qcq by Molmil
Crystal structure of Bone Morphogenetic Protein-3 (BMP-3)
分子名称: Bone morphogenetic protein 3
著者Allendorph, G.P.
登録日2007-06-19
公開日2007-10-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors.
Biochemistry, 46, 2007

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