5VZ3

Growth Factor Crystal Structure at 1.97 Angstrom Resolution

Summary for 5VZ3

Entry DOI	10.2210/pdb5vz3/pdb
Related	5VZ4
Descriptor	Growth/differentiation factor 15 (2 entities in total)
Functional Keywords	growth factor, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted : Q99988
Total number of polymer chains	1
Total formula weight	12303.25
Authors	Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2017-05-26, release date: 2017-09-27, Last modification date: 2017-10-25)
Primary citation	Hsu, J.Y.,Crawley, S.,Chen, M.,Ayupova, D.A.,Lindhout, D.A.,Higbee, J.,Kutach, A.,Joo, W.,Gao, Z.,Fu, D.,To, C.,Mondal, K.,Li, B.,Kekatpure, A.,Wang, M.,Laird, T.,Horner, G.,Chan, J.,McEntee, M.,Lopez, M.,Lakshminarasimhan, D.,White, A.,Wang, S.P.,Yao, J.,Yie, J.,Matern, H.,Solloway, M.,Haldankar, R.,Parsons, T.,Tang, J.,Shen, W.D.,Alice Chen, Y.,Tian, H.,Allan, B.B. Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature, 550:255-259, 2017 Cited by PubMed: 28953886 DOI: 10.1038/nature24042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation