2ARV

Structure of human Activin A

Summary for 2ARV

Related2ARP
DescriptorInhibin beta A chain, SULFATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywordshomodimer, cystine knot, disulfide linked, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P08476
Total number of polymer chains2
Total molecular weight26896.57
Authors
Harrington, A.E.,Morris-Triggs, S.A.,Ruotolo, B.T.,Robinson, C.V.,Ohnuma, S.,Hyvonen, M. (deposition date: 2005-08-22, release date: 2006-03-07, Last modification date: 2011-07-13)
Primary citation
Harrington, A.E.,Morris-Triggs, S.A.,Ruotolo, B.T.,Robinson, C.V.,Ohnuma, S.,Hyvonen, M.
Structural basis for the inhibition of activin signalling by follistatin
Embo J., 25:1035-1045, 2006
PubMed: 16482217 (PDB entries with the same primary citation)
DOI: 10.1038/sj.emboj.7601000
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23814 1.9% 6.6% 9.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02