5TX6
Structure of TGF-beta2 derivative with deletion of residues 52-71 and 10 single amino acid mutations (mmTGF-beta2-7M)
Summary for 5TX6
Entry DOI | 10.2210/pdb5tx6/pdb |
Related | 5TX2 5TX4 |
Descriptor | Transforming growth factor beta-2, CALCIUM ION (3 entities in total) |
Functional Keywords | growth factor, cytokine |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 3 |
Total formula weight | 31937.21 |
Authors | Petrunak, E.M.,Hinck, A.P. (deposition date: 2016-11-15, release date: 2017-03-01, Last modification date: 2019-12-04) |
Primary citation | Kim, S.K.,Barron, L.,Hinck, C.S.,Petrunak, E.M.,Cano, K.E.,Thangirala, A.,Iskra, B.,Brothers, M.,Vonberg, M.,Leal, B.,Richter, B.,Kodali, R.,Taylor, A.B.,Du, S.,Barnes, C.O.,Sulea, T.,Calero, G.,Hart, P.J.,Hart, M.J.,Demeler, B.,Hinck, A.P. An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. J. Biol. Chem., 292:7173-7188, 2017 Cited by PubMed: 28228478DOI: 10.1074/jbc.M116.768754 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.746 Å) |
Structure validation
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