5TX6
Structure of TGF-beta2 derivative with deletion of residues 52-71 and 10 single amino acid mutations (mmTGF-beta2-7M)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (B, A, C) | Transforming growth factor beta-2 | polymer | 93 | 10632.4 | 3 | UniProt (P27090) Pfam (PF00019) | Mus musculus (Mouse) | TGF-beta-2 |
| 2 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 3 | E, F, G (B, A, C) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
B, A, C: 1 - 112 (UniProt: P27090)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Arg 25 | Lys 327 | engineered mutation |
| Lys 26 | Arg 328 | engineered mutation |
| - | Leu 353 | deletion |
| - | Trp 354 | deletion |
| - | Ser 355 | deletion |
| - | Ser 356 | deletion |
| - | Asp 357 | deletion |
| - | Thr 358 | deletion |
| - | Gln 359 | deletion |
| - | His 360 | deletion |
| - | Thr 361 | deletion |
| - | Lys 362 | deletion |
| - | Val 363 | deletion |
| - | Leu 364 | deletion |
| - | Ser 365 | deletion |
| - | Leu 366 | deletion |
| - | Tyr 367 | deletion |
| - | Asn 368 | deletion |
| - | Thr 369 | deletion |
| - | Ile 370 | deletion |
| - | Asn 371 | deletion |
| - | Pro 372 | deletion |
| Arg 51 | Glu 373 | engineered mutation |
| Lys 74 | Ala 376 | engineered mutation |
| Ser 77 | Cys 379 | engineered mutation |
| Val 89 | Leu 391 | engineered mutation |
| Val 92 | Ile 394 | engineered mutation |
| Arg 94 | Asn 396 | engineered mutation |
| Lys 95 | Thr 397 | engineered mutation |
| Val 98 | Ile 400 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 31897.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 31937.2 |
