5F3H

Structure of myostatin in complex with humanized RK35 antibody

Summary for 5F3H

• Entry DOI: 10.2210/pdb5f3h/pdb
• Related: 5F3B
• Descriptor: humanized RK35 antibody heavy chain, humanized RK35 antibody light chain, Growth/differentiation factor 8 (3 entities in total)
• Functional Keywords: myostatin, antibody, complex, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Mus musculus; More
• Cellular location: Secreted: O14793
• Total number of polymer chains: 12
• Total formula weight: 236204.50

Authors

Parris, K.D.,Mosyak, L. (deposition date: 2015-12-02, release date: 2016-09-28, Last modification date: 2023-09-27)

• Primary citation: Apgar, J.R.,Mader, M.,Agostinelli, R.,Benard, S.,Bialek, P.,Johnson, M.,Gao, Y.,Krebs, M.,Owens, J.,Parris, K.,St Andre, M.,Svenson, K.,Morris, C.,Tchistiakova, L.; Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.; Mabs, 8:1302-1318, 2016; PubMed: 27625211; DOI: 10.1080/19420862.2016.1215786

Experimental method

X-RAY DIFFRACTION (2.7 Å)