5F3B

Structure of myostatin in complex with chimeric RK35 antibody

Summary for 5F3B

Entry DOI	10.2210/pdb5f3b/pdb
Descriptor	RK35 Chimeric antibody heavy chain, RK35 Chimeric antibody light chain, Growth/differentiation factor 8, ... (5 entities in total)
Functional Keywords	myostatin, antibody, complex, signaling protein-immune system complex, signaling protein/immune system
Biological source	Mus musculus More
Cellular location	Secreted: O14793
Total number of polymer chains	6
Total formula weight	119329.61
Authors	Parris, K.D.,Mosyak, L. (deposition date: 2015-12-02, release date: 2016-09-28, Last modification date: 2023-09-27)
Primary citation	Apgar, J.R.,Mader, M.,Agostinelli, R.,Benard, S.,Bialek, P.,Johnson, M.,Gao, Y.,Krebs, M.,Owens, J.,Parris, K.,St Andre, M.,Svenson, K.,Morris, C.,Tchistiakova, L. Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8:1302-1318, 2016 Cited by PubMed: 27625211 DOI: 10.1080/19420862.2016.1215786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation