6SF1

Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1).

Summary for 6SF1

Entry DOI	10.2210/pdb6sf1/pdb
Descriptor	Serine/threonine-protein kinase receptor R3, Bone morphogenetic protein 10, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	bmp10, alk1, complex, signalling, tgfbeta, bmp, cytokine
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	23258.78
Authors	Salmon, R.M.,Guo, J.,Yu, M.,Li, W. (deposition date: 2019-07-30, release date: 2020-04-08, Last modification date: 2024-01-24)
Primary citation	Salmon, R.M.,Guo, J.,Wood, J.H.,Tong, Z.,Beech, J.S.,Lawera, A.,Yu, M.,Grainger, D.J.,Reckless, J.,Morrell, N.W.,Li, W. Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11:1621-1621, 2020 Cited by PubMed: 32238803 DOI: 10.1038/s41467-020-15425-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation