5HMS
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![BU of 5hms by Molmil](/molmil-images/mine/5hms) | X-ray structure of human recombinant 5-aminolaevulinic acid dehydratase (hrALAD). | Descriptor: | Delta-aminolevulinic acid dehydratase, ZINC ION | Authors: | Butler, D, Erskine, P.T, Cooper, J.B, Shoolingin-Jordan, P.M. | Deposit date: | 2016-01-17 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis. Acta Crystallogr D Struct Biol, 73, 2017
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5HNB
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5H6G
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![BU of 5h6g by Molmil](/molmil-images/mine/5h6g) | Crystal structure of a thermostable lipase from Marine Streptomyces | Descriptor: | CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Hou, S, Zhao, Z, Liu, J. | Deposit date: | 2016-11-11 | Release date: | 2017-09-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal structure of a lipase from Streptomyces sp. strain W007 - implications for thermostability and regiospecificity FEBS J., 284, 2017
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6E6A
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![BU of 6e6a by Molmil](/molmil-images/mine/6e6a) | Triclinic crystal form of IncA G144A point mutant | Descriptor: | Inclusion membrane protein A, SODIUM ION | Authors: | Cingolani, G, Paumet, F. | Deposit date: | 2018-07-24 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA. Nat Commun, 10, 2019
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5H74
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![BU of 5h74 by Molmil](/molmil-images/mine/5h74) | Crystal structure of T2R-TTL-14b complex | Descriptor: | (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, Y, Yu, Y, Chen, Q, Yang, J. | Deposit date: | 2016-11-17 | Release date: | 2017-11-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin To Be Published
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5H6M
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![BU of 5h6m by Molmil](/molmil-images/mine/5h6m) | DNA targeting ADP-ribosyltransferase Pierisin-1 | Descriptor: | 1,2-ETHANEDIOL, Pierisin-1 | Authors: | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | Deposit date: | 2016-11-14 | Release date: | 2017-08-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
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5H84
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![BU of 5h84 by Molmil](/molmil-images/mine/5h84) | Human Gcn5 bound to propionyl-CoA | Descriptor: | 1,2-ETHANEDIOL, Histone acetyltransferase KAT2A, ISOPROPYL ALCOHOL, ... | Authors: | Wolberger, C, Ringel, A.E. | Deposit date: | 2015-12-23 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for acyl-group discrimination by human Gcn5L2. Acta Crystallogr D Struct Biol, 72, 2016
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5H86
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![BU of 5h86 by Molmil](/molmil-images/mine/5h86) | Human Gcn5 bound to butyryl-CoA | Descriptor: | 1,2-ETHANEDIOL, Butyryl Coenzyme A, Histone acetyltransferase KAT2A | Authors: | Wolberger, C, Ringel, A.E. | Deposit date: | 2015-12-23 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural basis for acyl-group discrimination by human Gcn5L2. Acta Crystallogr D Struct Biol, 72, 2016
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7MZ1
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1AP5
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6ELN
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![BU of 6eln by Molmil](/molmil-images/mine/6eln) | Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation | Descriptor: | 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol, Heat shock protein HSP 90-alpha, SULFATE ION | Authors: | Musil, D, Lehmann, M, Eggenweiler, H.-M. | Deposit date: | 2017-09-29 | Release date: | 2018-05-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Estimation of Drug-Target Residence Times by tau-Random Acceleration Molecular Dynamics Simulations. J Chem Theory Comput, 14, 2018
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6ELO
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1AP6
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1AYI
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![BU of 1ayi by Molmil](/molmil-images/mine/1ayi) | COLICIN E7 IMMUNITY PROTEIN IM7 | Descriptor: | COLICIN E IMMUNITY PROTEIN 7 | Authors: | Dennis, C.A, Pauptit, R.A, Wallis, R, James, R, Moore, G.R, Kleanthous, C. | Deposit date: | 1997-11-04 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity. Biochem.J., 333 ( Pt 1), 1998
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6ER2
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3O7W
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![BU of 3o7w by Molmil](/molmil-images/mine/3o7w) | The Crystal Structure of Human Leucine Carboxyl Methyltransferase 1 | Descriptor: | GLYCEROL, Leucine carboxyl methyltransferase 1, S-ADENOSYLMETHIONINE, ... | Authors: | Tsai, M.L, Cronin, N, Djordjevic, S. | Deposit date: | 2010-08-01 | Release date: | 2010-09-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A Acta Crystallogr.,Sect.D, 67, 2011
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6E6C
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![BU of 6e6c by Molmil](/molmil-images/mine/6e6c) | HRAS G13D bound to GppNHp (H13GNP) | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Johnson, C.W, Mattos, C. | Deposit date: | 2018-07-24 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28, 2019
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1BH0
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![BU of 1bh0 by Molmil](/molmil-images/mine/1bh0) | STRUCTURE OF A GLUCAGON ANALOG | Descriptor: | GLUCAGON | Authors: | Sturm, N.S, Lin, Y, Burley, S.K, Krstenansky, J.L, Ahn, J.-M, Azizeh, B.Y, Trivedi, D, Hruby, V.J. | Deposit date: | 1998-06-11 | Release date: | 1998-11-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity. J.Med.Chem., 41, 1998
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6E6H
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![BU of 6e6h by Molmil](/molmil-images/mine/6e6h) | NRAS G13D bound to GppNHp (N13GNP) | Descriptor: | GTPase NRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Johnson, C.W, Mattos, C. | Deposit date: | 2018-07-24 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28, 2019
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6ELK
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![BU of 6elk by Molmil](/molmil-images/mine/6elk) | C.elegans MnSOD-3 mutant - Q142H | Descriptor: | GLYCEROL, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Hunter, G.J, Trinh, C.H, Hunter, T. | Deposit date: | 2017-09-29 | Release date: | 2017-12-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron. Chemistry, 24, 2018
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7MX9
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3O8Z
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![BU of 3o8z by Molmil](/molmil-images/mine/3o8z) | Crystal structure of Spn1 (Iws1) core domain | Descriptor: | SULFATE ION, Transcription factor IWS1 | Authors: | McDonald, S.M, Close, D, Hill, C.P. | Deposit date: | 2010-08-03 | Release date: | 2010-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure and biological importance of the spn1-spt6 interaction, and its regulatory role in nucleosome binding. Mol.Cell, 40, 2010
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6EP7
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![BU of 6ep7 by Molmil](/molmil-images/mine/6ep7) | ARABIDOPSIS THALIANA GSTU23, GSH bound | Descriptor: | GLUTATHIONE, GLYCEROL, Glutathione S-transferase U23, ... | Authors: | Tossounian, M.A, Van Molle, I, Wahni, K, Jacques, S, Vertommen, D, Gevaert, K, Van Breusegem, F, Young, D, Rosado, L, Messens, J. | Deposit date: | 2017-10-11 | Release date: | 2018-04-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.947 Å) | Cite: | Disulfide bond formation protects Arabidopsis thaliana glutathione transferase tau 23 from oxidative damage. Biochim. Biophys. Acta, 1862, 2018
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6EB2
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![BU of 6eb2 by Molmil](/molmil-images/mine/6eb2) | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid | Descriptor: | (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid, Integrase | Authors: | Lindenberger, J.J, Kobe, M, Kvaratskhelia, M. | Deposit date: | 2018-08-03 | Release date: | 2019-03-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. ACS Med Chem Lett, 10, 2019
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6EY9
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