5H74
Crystal structure of T2R-TTL-14b complex
Summary for 5H74
Entry DOI | 10.2210/pdb5h74/pdb |
Descriptor | Tubulin alpha-1B chain, (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | tubulin, complex, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton: Q2XVP4 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 266218.17 |
Authors | |
Primary citation | Wang, Y.,Yu, Y.,Chen, Q.,Yang, J. Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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