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5KHR	Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C) Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A. Deposit date: 2016-06-15 Release date: 2016-08-24 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016
7OBE	X-ray structure of the phosphatase PAPP5 from Arabidopsis thaliana Descriptor: CHLORIDE ION, Isoform 2 of Serine/threonine-protein phosphatase 5, MANGANESE (II) ION Authors: von Horsten, S, Essen, L.-O. Deposit date: 2021-04-22 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3 Å) Cite: Conformational Change of Tetratricopeptide Repeats Region Triggers Activation of Phytochrome-Associated Protein Phosphatase 5. Front Plant Sci, 12, 2021
5JJT	Crystal structure of a type 5 serine/threonine protein phosphatase from Arabidopsis thaliana Descriptor: NICKEL (II) ION, Serine/threonine-protein phosphatase 5 Authors: Li, H.M, Pu, H. Deposit date: 2016-04-25 Release date: 2017-04-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.103 Å) Cite: Crystal structure of a type 5 serine/threonine protein phosphatase from Arabidopsis thaliana To Be Published
1KT1	Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes Descriptor: FK506-binding protein FKBP51, SULFATE ION Authors: Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. Deposit date: 2002-01-14 Release date: 2003-02-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: STRUCTURE OF THE LARGE FK506-BINDING PROTEIN FKBP51, AN HSP90-BINDING PROTEIN AND A COMPONENT OF STEROID RECEPTOR COMPLEXES Proc.Natl.Acad.Sci.USA, 100, 2003
5JHE	The Crystal Structure of the Saccharomyces cerevisiae Co-Chaperone Cpr7 Descriptor: Peptidyl-prolyl cis-trans isomerase CYP7 Authors: Yu, Q, Xu, L. Deposit date: 2016-04-20 Release date: 2017-04-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Crystal Structure of the Saccharomyces cerevisiae Co-Chaperone Cpr7 To Be Published
1KT0	Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes Descriptor: 51 KDA FK506-BINDING PROTEIN, SULFATE ION Authors: Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. Deposit date: 2002-01-14 Release date: 2003-02-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes Proc.Natl.Acad.Sci.USA, 100, 2003
6TM5	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: Alfieri, C, Barford, D. Deposit date: 2019-12-03 Release date: 2020-02-19 Last modified: 2020-06-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. Embo Rep., 21, 2020
2Y4T	Crystal structure of the human co-chaperone P58(IPK) Descriptor: DNAJ HOMOLOG SUBFAMILY C MEMBER 3 Authors: Svard, M, Biterova, E.I, Bourhis, J.-M, Guy, J.E. Deposit date: 2011-01-10 Release date: 2011-08-10 Method: X-RAY DIFFRACTION (3 Å) Cite: The Crystal Structure of the Human Co-Chaperone P58Ipk Plos One, 6, 2011
5G04	Structure of the human APC-Cdc20-Hsl1 complex Descriptor: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... Authors: Zhang, S, Chang, L, Alfieri, C, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. Deposit date: 2016-03-16 Release date: 2016-05-25 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation. Nature, 533, 2016
7L7I	Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex Descriptor: Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peptidyl-prolyl cis-trans isomerase FKBP5, ... Authors: Lee, K, Thwin, A.C, Tse, E, Gates, S.N, Southworth, D.R. Deposit date: 2020-12-28 Release date: 2021-08-25 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Mol.Cell, 81, 2021
7KW7	Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... Authors: Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. Deposit date: 2020-11-30 Release date: 2021-12-08 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
4JA7	Rat PP5 co-crystallized with P5SA-2 Descriptor: MAGNESIUM ION, Serine/threonine-protein phosphatase 5 Authors: Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K. Deposit date: 2013-02-18 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Biosci.Rep., 35, 2015
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FFV	Cryo-EM structure of the GR-Hsp90-FKBP52 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8GAE	Hsp90 provides platform for CRaf dephosphorylation by PP5 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... Authors: Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. Deposit date: 2023-02-22 Release date: 2023-04-26 Last modified: 2023-05-03 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
8GFT	Hsp90 provides platform for CRaf dephosphorylation by PP5 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... Authors: Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. Deposit date: 2023-03-08 Release date: 2023-05-03 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
5L9U	Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. Deposit date: 2016-06-11 Release date: 2016-09-14 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
5L9T	Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. Deposit date: 2016-06-11 Release date: 2016-10-26 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
5LCW	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 4.2 angstrom resolution Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: Alfieri, C, Chang, L, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. Deposit date: 2016-06-22 Release date: 2016-08-10 Last modified: 2019-10-23 Method: ELECTRON MICROSCOPY (4 Å) Cite: Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature, 536, 2016
5NJX	Human FKBP51 protein in complex with C-terminal peptide of Human HSP 90-alpha Descriptor: HSP90AA1 protein, Peptidyl-prolyl cis-trans isomerase FKBP5, SULFATE ION Authors: Kumar, R, Moche, M, Winblad, B, Pavlov, P. Deposit date: 2017-03-30 Release date: 2017-11-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep, 7, 2017
8A3T	S. cerevisiae APC/C-Cdh1 complex Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... Authors: Barford, D, Vazquez-Fernandez, E, Zhang, Z, Yang, J. Deposit date: 2022-06-09 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex To Be Published
7ZR5	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... Authors: Oberoi, J, Pearl, L.H. Deposit date: 2022-05-03 Release date: 2022-12-14 Last modified: 2022-12-21 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
7ZR6	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... Authors: Oberoi, J, Pearl, L.H. Deposit date: 2022-05-03 Release date: 2022-12-28 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022

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