5L9T
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
Summary for 5L9T
Entry DOI | 10.2210/pdb5l9t/pdb |
EMDB information | 3433 |
Descriptor | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 13, ... (17 entities in total) |
Functional Keywords | ubiquitination, multi-protein complex, cell division, conformational regulation, cell cycle |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q9BS18 P30260 Q8NHZ8 Isoform 2: Nucleus. Isoform 3: Cytoplasm: Q9UM11 Bud neck : P34244 Cytoplasm : Q9NYG5 Q96DE5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q13042 |
Total number of polymer chains | 22 |
Total formula weight | 1253349.97 |
Authors | Brown, N.G.,VanderLinden, R.,Dube, P.,Haselbach, D.,Peters, J.M.,Stark, H.,Schulman, B.A. (deposition date: 2016-06-11, release date: 2016-10-26, Last modification date: 2024-05-08) |
Primary citation | Brown, N.G.,VanderLinden, R.,Watson, E.R.,Weissmann, F.,Ordureau, A.,Wu, K.P.,Zhang, W.,Yu, S.,Mercredi, P.Y.,Harrison, J.S.,Davidson, I.F.,Qiao, R.,Lu, Y.,Dube, P.,Brunner, M.R.,Grace, C.R.,Miller, D.J.,Haselbach, D.,Jarvis, M.A.,Yamaguchi, M.,Yanishevski, D.,Petzold, G.,Sidhu, S.S.,Kuhlman, B.,Kirschner, M.W.,Harper, J.W.,Peters, J.M.,Stark, H.,Schulman, B.A. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165:1440-1453, 2016 Cited by PubMed: 27259151DOI: 10.1016/j.cell.2016.05.037 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.4 Å) |
Structure validation
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