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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5L9T

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Anaphase-promoting complex subunit 1polymer1944216725.51UniProt (Q9H1A4)
Pfam (PF12859)
Pfam (PF20518)
Pfam (PF21282)
Pfam (PF18122)		Homo sapiens (Human)APC1,Cyclosome subunit 1,Mitotic checkpoint regulator,Testis-specific gene 24 protein
2B
(B)		Anaphase-promoting complex subunit 11polymer849854.61UniProt (Q9NYG5)
Pfam (PF12861)		Homo sapiens (Human)APC11,Cyclosome subunit 11,Hepatocellular carcinoma-associated RING finger protein
3C, P
(C, P)		Cell division cycle protein 23 homologpolymer59768921.02UniProt (Q9UJX2)
Pfam (PF04049)		Homo sapiens (Human)Anaphase-promoting complex subunit 8,APC8,Cyclosome subunit 8
4D
(D)		Anaphase-promoting complex subunit 15polymer12114286.71UniProt (P60006)
Pfam (PF15243)		Homo sapiens (Human)APC15
5E
(E)		Anaphase-promoting complex subunit 16polymer11011678.01UniProt (Q96DE5)
Pfam (PF17256)		Homo sapiens (Human)APC16,Cyclosome subunit 16
6F, H
(F, H)		Cell division cycle protein 27 homologpolymer82491973.12UniProt (P30260)
Pfam (PF12895)
Pfam (PF00515)		Homo sapiens (Human)Anaphase-promoting complex subunit 3,APC3,CDC27 homolog,CDC27Hs,H-NUC
7G, T
(G, W)		Anaphase-promoting complex subunit CDC26polymer859794.02UniProt (Q8NHZ8)
Pfam (PF10471)		Homo sapiens (Human)Anaphase-promoting complex subunit 12,APC12,Cell division cycle protein 26 homolog
8I
(I)		Anaphase-promoting complex subunit 4polymer81893207.31UniProt (Q9UJX5)
Pfam (PF12894)
Pfam (PF12896)		Homo sapiens (Human)APC4,Cyclosome subunit 4
9J, K
(J, K)		Cell division cycle protein 16 homologpolymer62071747.52UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)		Homo sapiens (Human)Anaphase-promoting complex subunit 6,APC6,CDC16 homolog,CDC16Hs,Cyclosome subunit 6
10L
(L)		Anaphase-promoting complex subunit 10polymer18521282.11UniProt (Q9UM13)
Pfam (PF03256)		Homo sapiens (Human)APC10,Cyclosome subunit 10
11M
(M)		Anaphase-promoting complex subunit 13polymer748528.31UniProt (Q9BS18)
Pfam (PF05839)		Homo sapiens (Human)APC13,Cyclosome subunit 13
12N
(N)		Anaphase-promoting complex subunit 2polymer82293939.01UniProt (Q9UJX6)
Pfam (PF00888)
Pfam (PF08672)		Homo sapiens (Human)APC2,Cyclosome subunit 2
13O
(O)		Anaphase-promoting complex subunit 5polymer75585179.81UniProt (Q9UJX4)
Pfam (PF21371)
Pfam (PF12862)		Homo sapiens (Human)APC5,Cyclosome subunit 5
14Q
(R)		Fizzy-related protein homologpolymer49354838.71UniProt (Q9UM11)
Pfam (PF12894)
Pfam (PF00400)		Homo sapiens (Human)Fzr,CDC20-like protein 1,Cdh1/Hct1 homolog,hCDH1
15R
(S)		Ubiquitin_variant-Hsl1(substrate) fusionpolymer10812030.91UniProt (P0CG47)
UniProt (P34244)
Pfam (PF00240)		Homo sapiens (Human)
16S
(T)		Ubiquitin-conjugating enzyme E2 Spolymer18520519.71UniProt (Q16763)
Pfam (PF00179)		Homo sapiens (Human)E2 ubiquitin-conjugating enzyme S,E2-EPF,Ubiquitin carrier protein S,Ubiquitin-conjugating enzyme E2-24 kDa,Ubiquitin-conjugating enzyme E2-EPF5,Ubiquitin-protein ligase S
17U, V
(X, Y)		Anaphase-promoting complex subunit 7polymer56563204.02UniProt (Q9UJX3)
Pfam (PF13181)
Pfam (PF13432)		Homo sapiens (Human)APC7,Cyclosome subunit 7
Sequence modifications
I: 1 - 808 (UniProt: Q9UJX5)
PDBExternal DatabaseDetails
Gly 809-expression tag
Gly 810-expression tag
Ser 811-expression tag
Leu 812-expression tag
Glu 813-expression tag
Val 814-expression tag
Leu 815-expression tag
Phe 816-expression tag
Gln 817-expression tag
Gly 818-expression tag
S: 1 - 816 (UniProt: P0CG47)
PDBExternal DatabaseDetails
Gly -4-expression tag
Ser -3-expression tag
Gly -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Leu 4Phe 80engineered mutation
Pro 8Leu 84engineered mutation
Arg 9Thr 85engineered mutation
Cys 11Lys 87engineered mutation
Ile 42Arg 118engineered mutation
Phe 44Ile 120engineered mutation
Val 47Gly 123engineered mutation
Arg 49Gln 125engineered mutation
Lys 64Glu 140engineered mutation
Ser 66Thr 142engineered mutation
Leu 68His 144engineered mutation
Ala 70Val 146engineered mutation
Met 71Leu 147engineered mutation
Val 73Leu 149engineered mutation
Pro 74Arg 150engineered mutation
Lys 815Gly 152engineered mutation
Lys 817-linker
S: 818 - 842 (UniProt: P34244)
T: 1 - 181 (UniProt: Q16763)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Phe 118Cys 118conflict
-Gly 160deletion
-Pro 161deletion
-Ser 162deletion
-Gly 163deletion
-Arg 164deletion
-Ala 165deletion
-Glu 166deletion
-Ala 167deletion
-Gly 168deletion
-Arg 169deletion
-Ala 170deletion
-Leu 171deletion
-Ala 172deletion
-Ser 173deletion
-Gly 174deletion
-Thr 175deletion
-Glu 176deletion
-Ala 177deletion
-Ser 178deletion
-Ser 179deletion
-Thr 180deletion
-Asp 181deletion
-Pro 182deletion
-Gly 183deletion
-Ala 184deletion
-Pro 185deletion
-Gly 186deletion
-Gly 187deletion
-Pro 188deletion
-Gly 189deletion
-Gly 190deletion
-Ala 191deletion
-Glu 192deletion
-Gly 193deletion
-Pro 194deletion
-Met 195deletion
-Ala 196deletion
-Lys 197deletion
-Lys 198deletion
-His 199deletion
-Ala 200deletion
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains22
Total formula weight1253350.0
All*Total formula weight1253350.0
*Water molecules are not included.

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PDB entries from 2024-11-06

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