5L9U

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination

Summary for 5L9U

• Entry DOI: 10.2210/pdb5l9u/pdb
• EMDB information: 3432
• Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 13, ... (17 entities in total)
• Functional Keywords: ubiquitination, multi-protein complex, cell division, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 22
• Total formula weight: 1258625.00

Authors

Brown, N.G.,VanderLinden, R.,Dube, P.,Haselbach, D.,Peters, J.M.,Stark, H.,Schulman, B.A. (deposition date: 2016-06-11, release date: 2016-09-14, Last modification date: 2019-11-06)

• Primary citation: Brown, N.G.,VanderLinden, R.,Watson, E.R.,Weissmann, F.,Ordureau, A.,Wu, K.P.,Zhang, W.,Yu, S.,Mercredi, P.Y.,Harrison, J.S.,Davidson, I.F.,Qiao, R.,Lu, Y.,Dube, P.,Brunner, M.R.,Grace, C.R.,Miller, D.J.,Haselbach, D.,Jarvis, M.A.,Yamaguchi, M.,Yanishevski, D.,Petzold, G.,Sidhu, S.S.,Kuhlman, B.,Kirschner, M.W.,Harper, J.W.,Peters, J.M.,Stark, H.,Schulman, B.A.; Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.; Cell, 165:1440-1453, 2016; PubMed: 27259151; DOI: 10.1016/j.cell.2016.05.037

Experimental method

ELECTRON MICROSCOPY (6.4 Å)