5L9U

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005680	cellular_component	anaphase-promoting complex
A	0005829	cellular_component	cytosol
A	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016567	biological_process	protein ubiquitination
A	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
A	0051301	biological_process	cell division
A	0051445	biological_process	regulation of meiotic cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0141198	biological_process	protein branched polyubiquitination
B	0000278	biological_process	mitotic cell cycle
B	0001664	molecular_function	G protein-coupled receptor binding
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005680	cellular_component	anaphase-promoting complex
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
B	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0051445	biological_process	regulation of meiotic cell cycle
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0097602	molecular_function	cullin family protein binding
B	0141198	biological_process	protein branched polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005680	cellular_component	anaphase-promoting complex
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
C	0007096	biological_process	regulation of exit from mitosis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0016567	biological_process	protein ubiquitination
C	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0051301	biological_process	cell division
C	0051445	biological_process	regulation of meiotic cell cycle
C	0070936	biological_process	protein K48-linked ubiquitination
C	0070979	biological_process	protein K11-linked ubiquitination
C	0141198	biological_process	protein branched polyubiquitination
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005680	cellular_component	anaphase-promoting complex
D	0005829	cellular_component	cytosol
D	0007346	biological_process	regulation of mitotic cell cycle
D	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
D	0051301	biological_process	cell division
D	0051445	biological_process	regulation of meiotic cell cycle
D	0070936	biological_process	protein K48-linked ubiquitination
D	0070979	biological_process	protein K11-linked ubiquitination
D	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
D	0141198	biological_process	protein branched polyubiquitination
E	0000775	cellular_component	chromosome, centromeric region
E	0000776	cellular_component	kinetochore
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005680	cellular_component	anaphase-promoting complex
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007346	biological_process	regulation of mitotic cell cycle
E	0016567	biological_process	protein ubiquitination
E	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
E	0051301	biological_process	cell division
E	0051445	biological_process	regulation of meiotic cell cycle
E	0070936	biological_process	protein K48-linked ubiquitination
E	0070979	biological_process	protein K11-linked ubiquitination
E	0141198	biological_process	protein branched polyubiquitination
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005680	cellular_component	anaphase-promoting complex
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
F	0007346	biological_process	regulation of mitotic cell cycle
F	0016567	biological_process	protein ubiquitination
F	0019903	molecular_function	protein phosphatase binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0031175	biological_process	neuron projection development
F	0051301	biological_process	cell division
F	0051445	biological_process	regulation of meiotic cell cycle
F	0070936	biological_process	protein K48-linked ubiquitination
F	0070979	biological_process	protein K11-linked ubiquitination
F	0072686	cellular_component	mitotic spindle
F	0141198	biological_process	protein branched polyubiquitination
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005680	cellular_component	anaphase-promoting complex
G	0005829	cellular_component	cytosol
G	0007346	biological_process	regulation of mitotic cell cycle
G	0016567	biological_process	protein ubiquitination
G	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
G	0051301	biological_process	cell division
G	0051445	biological_process	regulation of meiotic cell cycle
G	0070936	biological_process	protein K48-linked ubiquitination
G	0070979	biological_process	protein K11-linked ubiquitination
G	0141198	biological_process	protein branched polyubiquitination
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005680	cellular_component	anaphase-promoting complex
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
H	0007346	biological_process	regulation of mitotic cell cycle
H	0016567	biological_process	protein ubiquitination
H	0019903	molecular_function	protein phosphatase binding
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0031175	biological_process	neuron projection development
H	0051301	biological_process	cell division
H	0051445	biological_process	regulation of meiotic cell cycle
H	0070936	biological_process	protein K48-linked ubiquitination
H	0070979	biological_process	protein K11-linked ubiquitination
H	0072686	cellular_component	mitotic spindle
H	0141198	biological_process	protein branched polyubiquitination
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005680	cellular_component	anaphase-promoting complex
I	0005829	cellular_component	cytosol
I	0007346	biological_process	regulation of mitotic cell cycle
I	0016567	biological_process	protein ubiquitination
I	0019903	molecular_function	protein phosphatase binding
I	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0034399	cellular_component	nuclear periphery
I	0051301	biological_process	cell division
I	0051445	biological_process	regulation of meiotic cell cycle
I	0070936	biological_process	protein K48-linked ubiquitination
I	0070979	biological_process	protein K11-linked ubiquitination
I	0141198	biological_process	protein branched polyubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005680	cellular_component	anaphase-promoting complex
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0007346	biological_process	regulation of mitotic cell cycle
J	0016567	biological_process	protein ubiquitination
J	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
J	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
J	0051301	biological_process	cell division
J	0051445	biological_process	regulation of meiotic cell cycle
J	0070936	biological_process	protein K48-linked ubiquitination
J	0070979	biological_process	protein K11-linked ubiquitination
J	0072686	cellular_component	mitotic spindle
J	0141198	biological_process	protein branched polyubiquitination
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005680	cellular_component	anaphase-promoting complex
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0007346	biological_process	regulation of mitotic cell cycle
K	0016567	biological_process	protein ubiquitination
K	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
K	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
K	0051301	biological_process	cell division
K	0051445	biological_process	regulation of meiotic cell cycle
K	0070936	biological_process	protein K48-linked ubiquitination
K	0070979	biological_process	protein K11-linked ubiquitination
K	0072686	cellular_component	mitotic spindle
K	0141198	biological_process	protein branched polyubiquitination
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005680	cellular_component	anaphase-promoting complex
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007346	biological_process	regulation of mitotic cell cycle
L	0016567	biological_process	protein ubiquitination
L	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
L	0051301	biological_process	cell division
L	0051445	biological_process	regulation of meiotic cell cycle
L	0070936	biological_process	protein K48-linked ubiquitination
L	0070979	biological_process	protein K11-linked ubiquitination
L	0141198	biological_process	protein branched polyubiquitination
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005680	cellular_component	anaphase-promoting complex
M	0007346	biological_process	regulation of mitotic cell cycle
M	0016567	biological_process	protein ubiquitination
M	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
M	0051301	biological_process	cell division
M	0051445	biological_process	regulation of meiotic cell cycle
M	0070936	biological_process	protein K48-linked ubiquitination
M	0070979	biological_process	protein K11-linked ubiquitination
M	0141198	biological_process	protein branched polyubiquitination
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005680	cellular_component	anaphase-promoting complex
N	0005829	cellular_component	cytosol
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
N	0007346	biological_process	regulation of mitotic cell cycle
N	0007399	biological_process	nervous system development
N	0010498	biological_process	proteasomal protein catabolic process
N	0010629	biological_process	negative regulation of gene expression
N	0016567	biological_process	protein ubiquitination
N	0030154	biological_process	cell differentiation
N	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
N	0031461	cellular_component	cullin-RING ubiquitin ligase complex
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0031915	biological_process	positive regulation of synaptic plasticity
N	0045773	biological_process	positive regulation of axon extension
N	0050775	biological_process	positive regulation of dendrite morphogenesis
N	0051301	biological_process	cell division
N	0051445	biological_process	regulation of meiotic cell cycle
N	0070936	biological_process	protein K48-linked ubiquitination
N	0070979	biological_process	protein K11-linked ubiquitination
N	0090129	biological_process	positive regulation of synapse maturation
N	0141198	biological_process	protein branched polyubiquitination
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005680	cellular_component	anaphase-promoting complex
O	0005737	cellular_component	cytoplasm
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0007346	biological_process	regulation of mitotic cell cycle
O	0016567	biological_process	protein ubiquitination
O	0019903	molecular_function	protein phosphatase binding
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0051301	biological_process	cell division
O	0051445	biological_process	regulation of meiotic cell cycle
O	0070936	biological_process	protein K48-linked ubiquitination
O	0070979	biological_process	protein K11-linked ubiquitination
O	0141198	biological_process	protein branched polyubiquitination
P	0000278	biological_process	mitotic cell cycle
P	0004842	molecular_function	ubiquitin-protein transferase activity
P	0005515	molecular_function	protein binding
P	0005654	cellular_component	nucleoplasm
P	0005680	cellular_component	anaphase-promoting complex
P	0005829	cellular_component	cytosol
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0007080	biological_process	mitotic metaphase chromosome alignment
P	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
P	0007096	biological_process	regulation of exit from mitosis
P	0007346	biological_process	regulation of mitotic cell cycle
P	0016567	biological_process	protein ubiquitination
P	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
P	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
P	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
P	0051301	biological_process	cell division
P	0051445	biological_process	regulation of meiotic cell cycle
P	0070936	biological_process	protein K48-linked ubiquitination
P	0070979	biological_process	protein K11-linked ubiquitination
P	0141198	biological_process	protein branched polyubiquitination
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005680	cellular_component	anaphase-promoting complex
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006974	biological_process	DNA damage response
R	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
R	0007346	biological_process	regulation of mitotic cell cycle
R	0008284	biological_process	positive regulation of cell population proliferation
R	0010997	molecular_function	anaphase-promoting complex binding
R	0016567	biological_process	protein ubiquitination
R	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
R	0031965	cellular_component	nuclear membrane
R	0040020	biological_process	regulation of meiotic nuclear division
R	0046105	biological_process	thymidine biosynthetic process
R	0051301	biological_process	cell division
R	0051445	biological_process	regulation of meiotic cell cycle
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070306	biological_process	lens fiber cell differentiation
R	0070979	biological_process	protein K11-linked ubiquitination
R	0097027	molecular_function	ubiquitin-protein transferase activator activity
R	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
R	1904860	biological_process	DNA synthesis involved in mitotic DNA replication
R	1905786	biological_process	positive regulation of anaphase-promoting complex-dependent catabolic process
R	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
R	1990757	molecular_function	ubiquitin ligase activator activity
R	2000773	biological_process	negative regulation of cellular senescence
U	0000151	cellular_component	ubiquitin ligase complex
U	0000166	molecular_function	nucleotide binding
U	0000209	biological_process	protein polyubiquitination
U	0004842	molecular_function	ubiquitin-protein transferase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005680	cellular_component	anaphase-promoting complex
U	0005829	cellular_component	cytosol
U	0005886	cellular_component	plasma membrane
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0010458	biological_process	exit from mitosis
U	0010994	biological_process	free ubiquitin chain polymerization
U	0016567	biological_process	protein ubiquitination
U	0016740	molecular_function	transferase activity
U	0019787	molecular_function	ubiquitin-like protein transferase activity
U	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
U	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
U	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
U	0031536	biological_process	positive regulation of exit from mitosis
U	0032446	biological_process	protein modification by small protein conjugation
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0044389	molecular_function	ubiquitin-like protein ligase binding
U	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
U	0051301	biological_process	cell division
U	0061630	molecular_function	ubiquitin protein ligase activity
U	0061631	molecular_function	ubiquitin conjugating enzyme activity
U	0070936	biological_process	protein K48-linked ubiquitination
U	0070979	biological_process	protein K11-linked ubiquitination
U	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005680	cellular_component	anaphase-promoting complex
W	0005829	cellular_component	cytosol
W	0007346	biological_process	regulation of mitotic cell cycle
W	0016567	biological_process	protein ubiquitination
W	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
W	0051301	biological_process	cell division
W	0051445	biological_process	regulation of meiotic cell cycle
W	0070936	biological_process	protein K48-linked ubiquitination
W	0070979	biological_process	protein K11-linked ubiquitination
W	0141198	biological_process	protein branched polyubiquitination
X	0000792	cellular_component	heterochromatin
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005680	cellular_component	anaphase-promoting complex
X	0005737	cellular_component	cytoplasm
X	0005819	cellular_component	spindle
X	0005829	cellular_component	cytosol
X	0005856	cellular_component	cytoskeleton
X	0007346	biological_process	regulation of mitotic cell cycle
X	0007420	biological_process	brain development
X	0015630	cellular_component	microtubule cytoskeleton
X	0016567	biological_process	protein ubiquitination
X	0019903	molecular_function	protein phosphatase binding
X	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
X	0045171	cellular_component	intercellular bridge
X	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
X	0051301	biological_process	cell division
X	0051445	biological_process	regulation of meiotic cell cycle
X	0070936	biological_process	protein K48-linked ubiquitination
X	0070979	biological_process	protein K11-linked ubiquitination
X	0072686	cellular_component	mitotic spindle
X	0140767	molecular_function	enzyme-substrate adaptor activity
X	0141198	biological_process	protein branched polyubiquitination
Y	0000792	cellular_component	heterochromatin
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005680	cellular_component	anaphase-promoting complex
Y	0005737	cellular_component	cytoplasm
Y	0005819	cellular_component	spindle
Y	0005829	cellular_component	cytosol
Y	0005856	cellular_component	cytoskeleton
Y	0007346	biological_process	regulation of mitotic cell cycle
Y	0007420	biological_process	brain development
Y	0015630	cellular_component	microtubule cytoskeleton
Y	0016567	biological_process	protein ubiquitination
Y	0019903	molecular_function	protein phosphatase binding
Y	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Y	0045171	cellular_component	intercellular bridge
Y	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
Y	0051301	biological_process	cell division
Y	0051445	biological_process	regulation of meiotic cell cycle
Y	0070936	biological_process	protein K48-linked ubiquitination
Y	0070979	biological_process	protein K11-linked ubiquitination
Y	0072686	cellular_component	mitotic spindle
Y	0140767	molecular_function	enzyme-substrate adaptor activity
Y	0141198	biological_process	protein branched polyubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVdtq.GnICLdiL

Chain	Residue	Details
U	TYR103-LEU118

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. SGGGtaDrCIRFWNT

Chain	Residue	Details
R	SER373-THR387
R	ILE458-VAL472

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Repeat: {"description":"PC 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	38
Details	Repeat: {"description":"PC 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	34
Details	Repeat: {"description":"PC 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	294
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	298
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	242
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	290
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	271
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	199
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	209
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	215
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	217
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	223
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	192
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"14657031","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	159
Details	Repeat: {"description":"TPR 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	103
Details	Repeat: {"description":"TPR 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	58
Details	Repeat: {"description":"TPR 14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14657031","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14657031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8BZQ7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BZQ7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	40
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	37
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	42
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	41
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	5
Details	Region: {"description":"Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity","evidences":[{"source":"PubMed","id":"26083744","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	14
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22014574","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WVM3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---