6M63
| Crystal structure of a cAMP sensor G-Flamp1. | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein | Authors: | Zhou, Z, Chen, S, Wang, L, Chu, J. | Deposit date: | 2020-03-12 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging. Nat Commun, 13, 2022
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6MKS
| Cryo-EM structure of NLRC4-CARD filament | Descriptor: | Chimera protein of NLR family CARD domain-containing protein 4 and EGFP | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2018-09-26 | Release date: | 2018-11-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly. J. Biol. Chem., 293, 2018
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6ITC
| Structure of a substrate engaged SecA-SecY protein translocation machine | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Ma, C.Y, Wu, X.F, Sun, D.J, Park, E.Y, Rapoport, T.A, Gao, N, Long, L. | Deposit date: | 2018-11-21 | Release date: | 2019-06-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure of the substrate-engaged SecA-SecY protein translocation machine. Nat Commun, 10, 2019
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6MWQ
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8B6S
| X-ray structure of the haloalkane dehalogenase HaloTag7 fusion to the green fluorescent protein GFP (ChemoG1) labeled with a chloroalkane tetramethylrhodamine fluorophore substrate | Descriptor: | CHLORIDE ION, GLYCEROL, Green fluorescent protein,Haloalkane dehalogenase, ... | Authors: | Tarnawski, M, Hellweg, L, Hiblot, J. | Deposit date: | 2022-09-27 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A general method for the development of multicolor biosensors with large dynamic ranges. Nat.Chem.Biol., 19, 2023
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8B6T
| X-ray structure of the interface optimized haloalkane dehalogenase HaloTag7 fusion to the green fluorescent protein GFP (ChemoG5-TMR) labeled with a chloroalkane tetramethylrhodamine fluorophore substrate | Descriptor: | CHLORIDE ION, Green fluorescent protein,Haloalkane dehalogenase, [9-[2-carboxy-5-[2-[2-(6-chloranylhexoxy)ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium | Authors: | Tarnawski, M, Hellweg, L, Hiblot, J. | Deposit date: | 2022-09-27 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A general method for the development of multicolor biosensors with large dynamic ranges. Nat.Chem.Biol., 19, 2023
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8BAV
| Secretagogin (human) in complex with its target peptide from SNAP-25 | Descriptor: | ACETATE ION, CALCIUM ION, Green fluorescent protein,Synaptosomal-associated protein 25, ... | Authors: | Schnell, R, Szodorai, E. | Deposit date: | 2022-10-12 | Release date: | 2024-04-03 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TLM
| Structure of a class A GPCR/Fab complex | Descriptor: | C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ... | Authors: | Sun, D, Johnson, M, Masureel, M. | Deposit date: | 2023-07-27 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
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8T6L
| Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B | Descriptor: | (1R)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-9,12-dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl benzoate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... | Authors: | Tonggu, L, Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | Deposit date: | 2023-06-16 | Release date: | 2024-03-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin. Nat Commun, 15, 2024
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8TC3
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8T6K
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8T6Q
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8U4O
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8U4S
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8U4R
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8U4Q
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8U4N
| Structure of Apo CXCR4/Gi complex | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | Deposit date: | 2023-09-11 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Structural insights into CXCR4 modulation and oligomerization Biorxiv, 2024
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8U4P
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8W2L
| TRPM7 structure in complex with anticancer agent CCT128930 in closed state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium, ... | Authors: | Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2024-02-20 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Cell Rep, 43, 2024
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3VHT
| Crystal structure of GFP-Wrnip1 UBZ domain fusion protein in complex with ubiquitin | Descriptor: | Green fluorescent protein, Green fluorescent protein,ATPase WRNIP1, Ubiquitin, ... | Authors: | Suzuki, N, Wakatsuki, S, Kawasaki, M. | Deposit date: | 2011-09-06 | Release date: | 2012-10-10 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. Febs J., 2016
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3AI5
| Crystal structure of yeast enhanced green fluorescent protein-ubiquitin fusion protein | Descriptor: | 1,2-ETHANEDIOL, yeast enhanced green fluorescent protein,Ubiquitin | Authors: | Suzuki, N, Wakatsuki, S, Kawasaki, M. | Deposit date: | 2010-05-10 | Release date: | 2010-09-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystallization of small proteins assisted by green fluorescent protein Acta Crystallogr.,Sect.D, 66, 2010
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6ZUI
| Crystal structure of the Cys-Ser mutant of the cpYFP-based biosensor for hypochlorous acid | Descriptor: | HTH-type transcriptional repressor NemR,Green fluorescent protein,Green fluorescent protein,HTH-type transcriptional repressor NemR | Authors: | Tossounian, M.A, Van Molle, I, Messens, J. | Deposit date: | 2020-07-23 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.200082 Å) | Cite: | Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives. Nat Commun, 13, 2022
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7AA5
| Human TRPV4 structure in presence of 4a-PDD | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein | Authors: | Botte, M, Ulrich, A.K.G, Adaixo, R, Gnutt, D, Brockmann, A, Bucher, D, Chami, M, Bocquet, M, Ebbinghaus-Kintscher, U, Puetter, V, Becker, A, Egner, U, Stahlberg, H, Hennig, M, Holton, S.J. | Deposit date: | 2020-09-03 | Release date: | 2021-08-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation To Be Published
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7BYM
| Cryo-EM structure of human KCNQ4 with retigabine | Descriptor: | Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ... | Authors: | Shen, H, Li, T, Yue, Z. | Deposit date: | 2020-04-23 | Release date: | 2020-12-02 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Mol.Cell, 81, 2021
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7BYL
| Cryo-EM structure of human KCNQ4 | Descriptor: | Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ... | Authors: | Shen, H, Li, T, Yue, Z. | Deposit date: | 2020-04-23 | Release date: | 2020-12-02 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Mol.Cell, 81, 2021
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