8T6L

Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B

Summary for 8T6L

• Entry DOI: 10.2210/pdb8t6l/pdb
• EMDB information: 41071
• Descriptor: Sodium channel protein type 5 subunit alpha,Green fluorescent protein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: ion channel, sodium channel, voltage-gated channel, sodium transport, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 1
• Total formula weight: 231783.45

Authors

Tonggu, L.,Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. (deposition date: 2023-06-16, release date: 2024-03-06, Last modification date: 2024-03-27)

• Primary citation: Tonggu, L.,Wisedchaisri, G.,Gamal El-Din, T.M.,Lenaeus, M.J.,Logan, M.M.,Toma, T.,Du Bois, J.,Zheng, N.,Catterall, W.A.; Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.; Nat Commun, 15:2306-2306, 2024; PubMed: 38485923; DOI: 10.1038/s41467-024-45958-w

Experimental method

ELECTRON MICROSCOPY (3.3 Å)