8W2L

TRPM7 structure in complex with anticancer agent CCT128930 in closed state

Summary for 8W2L

Entry DOI	10.2210/pdb8w2l/pdb
EMDB information	43751
Descriptor	Green fluorescent protein,Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ... (7 entities in total)
Functional Keywords	transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, cct128930
Biological source	Aequorea victoria More
Total number of polymer chains	4
Total formula weight	747574.04
Authors	Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2024-02-20, release date: 2024-04-17, Last modification date: 2024-04-24)
Primary citation	Nadezhdin, K.D.,Correia, L.,Shalygin, A.,Aktolun, M.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I. Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Cell Rep, 43:114108-114108, 2024 Cited by PubMed: 38615321 DOI: 10.1016/j.celrep.2024.114108 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.45 Å)

Structure validation