8W2L
TRPM7 structure in complex with anticancer agent CCT128930 in closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Green fluorescent protein,Transient receptor potential cation channel subfamily M member 7 | polymer | 1534 | 175756.3 | 4 | UniProt (P42212) UniProt (Q923J1) Pfam (PF18139) Pfam (PF25508) Pfam (PF00520) Pfam (PF16519) | Aequorea victoria | |
| 2 | BA, BB, CA, DA, DB... (B, D, A, C) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 52 | Chemie (POV) | |||
| 3 | AA, H, IB, QA (B, A, D, C) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 4 | IA, P, QB, YA (B, A, D, C) | 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium | non-polymer | 342.8 | 4 | Chemie (M05) | |||
| 5 | AB, CB, KA, R (C, D, B, A) | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol | non-polymer | 516.8 | 4 | Chemie (DU0) | |||
| 6 | U (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | RB, SB, TB, UB (A, B, C, D) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -243 - -7 (UniProt: P42212)
A, B, C, D: 3 - 1280 (UniProt: Q923J1)
| PDB | External Database | Details |
|---|---|---|
| Met -253 | - | initiating methionine |
| Trp -252 | - | expression tag |
| Ser -251 | - | expression tag |
| His -250 | - | expression tag |
| Pro -249 | - | expression tag |
| Gln -248 | - | expression tag |
| Phe -247 | - | expression tag |
| Glu -246 | - | expression tag |
| Lys -245 | - | expression tag |
| Val -244 | - | expression tag |
| Leu -181 | Phe 64 | conflict |
| Thr -180 | Ser 65 | conflict |
| Lys -39 | Ala 206 | conflict |
| Leu -14 | His 231 | conflict |
| Val -6 | - | linker |
| Asp -5 | - | linker |
| Leu -4 | - | linker |
| Val -3 | - | linker |
| Pro -2 | - | linker |
| Arg -1 | - | linker |
| Gly 0 | - | linker |
| Ser 1 | - | linker |
| Ala 2 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 703025.0 | |
| Non-Polymers* | Number of molecules | 65 |
| Total formula weight | 44549.0 | |
| All* | Total formula weight | 747574.0 |
