8W2L
TRPM7 structure in complex with anticancer agent CCT128930 in closed state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| A | 0051262 | biological_process | protein tetramerization |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0008218 | biological_process | bioluminescence |
| B | 0051262 | biological_process | protein tetramerization |
| C | 0006091 | biological_process | generation of precursor metabolites and energy |
| C | 0008218 | biological_process | bioluminescence |
| C | 0051262 | biological_process | protein tetramerization |
| D | 0006091 | biological_process | generation of precursor metabolites and energy |
| D | 0008218 | biological_process | bioluminescence |
| D | 0051262 | biological_process | protein tetramerization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 144 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 92 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 160 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 112 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q96QT4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q96QT4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22222377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
