7BYM

Cryo-EM structure of human KCNQ4 with retigabine

Summary for 7BYM

• Entry DOI: 10.2210/pdb7bym/pdb
• EMDB information: 30245
• Descriptor: Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, Calmodulin-3, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... (6 entities in total)
• Functional Keywords: kcnq, channel, calmodulin, pip2, retigabine, membrane protein
• Biological source: Aequorea victoria (Jellyfish); More
• Total number of polymer chains: 8
• Total formula weight: 510240.49

Authors

Shen, H.,Li, T.,Yue, Z. (deposition date: 2020-04-23, release date: 2020-12-02, Last modification date: 2024-03-27)

• Primary citation: Li, T.,Wu, K.,Yue, Z.,Wang, Y.,Zhang, F.,Shen, H.; Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.; Mol.Cell, 81:25-, 2021; PubMed: 33238160; DOI: 10.1016/j.molcel.2020.10.037

Experimental method

ELECTRON MICROSCOPY (3.1 Å)