6SP6
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![BU of 6sp6 by Molmil](/molmil-images/mine/6sp6) | Ultra-high Resolution Crystal Structure of the CTX-M-15 Extended-Spectrum beta-Lactamase in Complex with Taniborbactam (VNRX-5133) | Descriptor: | (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase, ... | Authors: | Docquier, J.D, Pozzi, C, De Luca, F, Benvenuti, M, Mangani, S. | Deposit date: | 2019-08-31 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J.Med.Chem., 63, 2020
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6TD1
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![BU of 6td1 by Molmil](/molmil-images/mine/6td1) | Crystal structure of VNRX-5133 (taniborbactam) bound to KPC-2 | Descriptor: | (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2019-11-07 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition. Rsc Med Chem, 11, 2020
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1TDL
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![BU of 1tdl by Molmil](/molmil-images/mine/1tdl) | Structure of Ser130Gly SHV-1 beta-lactamase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Sun, T, Bethel, C.R, Bonomo, R.A, Knox, J.R. | Deposit date: | 2004-05-23 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant Biochemistry, 43, 2004
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6TS9
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![BU of 6ts9 by Molmil](/molmil-images/mine/6ts9) | Crystal structure of GES-5 carbapenemase | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, Beta-lactamase, ... | Authors: | Maso, L, Tondi, D, Klein, R, Montanari, M, Bellio, C, Celenza, G, Brenk, R, Cendron, L. | Deposit date: | 2019-12-20 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Targeting the Class A Carbapenemase GES-5 via Virtual Screening. Biomolecules, 10, 2020
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6TD0
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![BU of 6td0 by Molmil](/molmil-images/mine/6td0) | Crystal structure of vaborbactam bound to KPC-2 | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION, ... | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2019-11-07 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition. Rsc Med Chem, 11, 2020
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1SHV
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![BU of 1shv by Molmil](/molmil-images/mine/1shv) | STRUCTURE OF SHV-1 BETA-LACTAMASE | Descriptor: | CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, PROTEIN (BETA-LACTAMASE SHV-1) | Authors: | Kuzin, A.P, Nukaga, M, Nukaga, Y, Hujer, A, Bonomo, R.A, Knox, J.R. | Deposit date: | 1999-02-23 | Release date: | 1999-05-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structure of the SHV-1 beta-lactamase. Biochemistry, 38, 1999
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1TDG
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![BU of 1tdg by Molmil](/molmil-images/mine/1tdg) | Complex of S130G SHV-1 beta-lactamase with tazobactam | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase SHV-1, ... | Authors: | Sun, T, Bethel, C.R, Bonomo, R.A, Knox, J.R. | Deposit date: | 2004-05-21 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant Biochemistry, 43, 2004
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1VM1
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![BU of 1vm1 by Molmil](/molmil-images/mine/1vm1) | STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM | Descriptor: | ACRYLIC ACID, BETA-LACTAMASE SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... | Authors: | Kuzin, A.P, Nukaga, M, Nukaga, Y, Hujer, A, Bonomo, R.A, Knox, J.R. | Deposit date: | 2004-08-27 | Release date: | 2004-09-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam. Biochemistry, 40, 2001
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7R3R
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![BU of 7r3r by Molmil](/molmil-images/mine/7r3r) | Crystal structure of CTX-M-15 G238C mutant apoenzyme | Descriptor: | Beta-lactamase, CHLORIDE ION, SULFATE ION | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2022-02-07 | Release date: | 2022-05-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 13, 2022
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7R3Q
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![BU of 7r3q by Molmil](/molmil-images/mine/7r3q) | |
7S0V
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![BU of 7s0v by Molmil](/molmil-images/mine/7s0v) | |
7S5S
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![BU of 7s5s by Molmil](/molmil-images/mine/7s5s) | CTX-M-15 WT in complex with BLIP WT | Descriptor: | Beta-lactamase, Beta-lactamase inhibitory protein | Authors: | Lu, S, Palzkill, T, Hu, L.Y, Prasad, B.V.V, Sankaran, B. | Deposit date: | 2021-09-11 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M beta-lactamase drug-resistance enzymes. Nat Commun, 13, 2022
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7TBX
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![BU of 7tbx by Molmil](/molmil-images/mine/7tbx) | Crystal structure of D179Y KPC-2 beta-lactamase | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC | Authors: | van den Akker, F, Alsenani, T. | Deposit date: | 2021-12-22 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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7TC1
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![BU of 7tc1 by Molmil](/molmil-images/mine/7tc1) | |
7TB7
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![BU of 7tb7 by Molmil](/molmil-images/mine/7tb7) | Crystal structure of D179N KPC-2 beta-lactamase | Descriptor: | CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC | Authors: | van den Akker, F, Alsenani, T. | Deposit date: | 2021-12-21 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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7TI0
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![BU of 7ti0 by Molmil](/molmil-images/mine/7ti0) | Structure of CTX-M-15 bound to RPX-7063 at 1.5A | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Clifton, M.C, Abendroth, J, Hecker, S.J, Edwards, T.E. | Deposit date: | 2022-01-12 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62, 2022
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7U4B
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![BU of 7u4b by Molmil](/molmil-images/mine/7u4b) | Ampicillin-CTX-M-15 | Descriptor: | (2S,4S)-2-[(1S)-1-{[(2S)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, SULFATE ION | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-02-28 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U57
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![BU of 7u57 by Molmil](/molmil-images/mine/7u57) | apo-CTX-M-15 | Descriptor: | Beta-lactamase, SULFATE ION | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-03-01 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U49
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![BU of 7u49 by Molmil](/molmil-images/mine/7u49) | DFC-CTX-M-15 | Descriptor: | (2R,4S,5R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-5-(sulfanylmethyl)-1,3-thiazinane-4-carboxylic acid, Beta-lactamase | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-02-28 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U48
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![BU of 7u48 by Molmil](/molmil-images/mine/7u48) | Clavulanic acid-CTX-M-15 | Descriptor: | (E)-5-hydroxy-3-oxo-N-(3-oxopropylidene)-L-norvaline, Beta-lactamase, GLYCEROL, ... | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-02-28 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U6Q
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![BU of 7u6q by Molmil](/molmil-images/mine/7u6q) | TEM-1 beta-lactamase | Descriptor: | Beta-lactamase, SULFATE ION | Authors: | Ji, Z, Boxer, S.G, Mathews, I.I. | Deposit date: | 2022-03-04 | Release date: | 2022-09-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases. J.Am.Chem.Soc., 144, 2022
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6WGR
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![BU of 6wgr by Molmil](/molmil-images/mine/6wgr) | The crystal structure of a beta-lactamase from Staphylococcus aureus subsp. aureus USA300_TCH1516 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase, GLYCEROL | Authors: | Tan, K, Wu, R, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-06 | Release date: | 2020-04-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | The crystal structure of a beta-lactamase from Staphylococcus aureus subsp. aureus USA300_TCH1516 To Be Published
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6WGP
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![BU of 6wgp by Molmil](/molmil-images/mine/6wgp) | The crystal structure of a beta lactamase from Xanthomonas campestris pv. campestris str. ATCC 33913 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase, ... | Authors: | Tan, K, Wu, R, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-06 | Release date: | 2020-04-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The crystal structure of a beta lactamase from Xanthomonas campestris pv. campestris str. ATCC 33913 To Be Published
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4ZJ1
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![BU of 4zj1 by Molmil](/molmil-images/mine/4zj1) | Crystal Structure of p-acrylamido-phenylalanine modified TEM1 beta-lactamase from Escherichia coli : V216AcrF mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase TEM, DI(HYDROXYETHYL)ETHER, ... | Authors: | Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, R.C, Schultz, P.G. | Deposit date: | 2015-04-28 | Release date: | 2015-05-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Exploring the potential impact of an expanded genetic code on protein function. Proc.Natl.Acad.Sci.USA, 112, 2015
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4ZBE
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![BU of 4zbe by Molmil](/molmil-images/mine/4zbe) | |