7TBX

Crystal structure of D179Y KPC-2 beta-lactamase

Summary for 7TBX

• Entry DOI: 10.2210/pdb7tbx/pdb
• Related: 7TB7
• Descriptor: Carbapenem-hydrolyzing beta-lactamase KPC (1 entity in total)
• Functional Keywords: beta-lactamase, antibiotic resistance, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 56651.86

Authors

van den Akker, F.,Alsenani, T. (deposition date: 2021-12-22, release date: 2022-03-02, Last modification date: 2023-10-18)

• Primary citation: Alsenani, T.A.,Viviani, S.L.,Kumar, V.,Taracila, M.A.,Bethel, C.R.,Barnes, M.D.,Papp-Wallace, K.M.,Shields, R.K.,Nguyen, M.H.,Clancy, C.J.,Bonomo, R.A.,van den Akker, F.; Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam.; Antimicrob.Agents Chemother., 66:e0241421-e0241421, 2022; PubMed: 35341315; DOI: 10.1128/aac.02414-21

Experimental method

X-RAY DIFFRACTION (3.16 Å)