7TB7
Crystal structure of D179N KPC-2 beta-lactamase
Summary for 7TB7
| Entry DOI | 10.2210/pdb7tb7/pdb |
| Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, CITRIC ACID (3 entities in total) |
| Functional Keywords | beta-lactamase, antibiotic resistance, hydrolase |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 28367.88 |
| Authors | van den Akker, F.,Alsenani, T. (deposition date: 2021-12-21, release date: 2022-03-02, Last modification date: 2023-10-18) |
| Primary citation | Alsenani, T.A.,Viviani, S.L.,Kumar, V.,Taracila, M.A.,Bethel, C.R.,Barnes, M.D.,Papp-Wallace, K.M.,Shields, R.K.,Nguyen, M.H.,Clancy, C.J.,Bonomo, R.A.,van den Akker, F. Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66:e0241421-e0241421, 2022 Cited by PubMed: 35341315DOI: 10.1128/aac.02414-21 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.99 Å) |
Structure validation
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