6SP6
Ultra-high Resolution Crystal Structure of the CTX-M-15 Extended-Spectrum beta-Lactamase in Complex with Taniborbactam (VNRX-5133)
Summary for 6SP6
Entry DOI | 10.2210/pdb6sp6/pdb |
Descriptor | Beta-lactamase, SULFATE ION, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, ... (6 entities in total) |
Functional Keywords | beta-lactamase, hydrolase, antibiotic resistance, beta-lactam hydrolysis |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 29154.57 |
Authors | Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2019-08-31, release date: 2020-01-22, Last modification date: 2024-01-24) |
Primary citation | Liu, B.,Trout, R.E.L.,Chu, G.H.,McGarry, D.,Jackson, R.W.,Hamrick, J.C.,Daigle, D.M.,Cusick, S.M.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S.,Docquier, J.D.,Weiss, W.J.,Pevear, D.C.,Xerri, L.,Burns, C.J. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J.Med.Chem., 63:2789-2801, 2020 Cited by PubMed: 31765155DOI: 10.1021/acs.jmedchem.9b01518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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