6TD1
Crystal structure of VNRX-5133 (taniborbactam) bound to KPC-2
Summary for 6TD1
Entry DOI | 10.2210/pdb6td1/pdb |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, boronate, beta-lactamase, antimicrobial protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 31480.11 |
Authors | Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2019-11-07, release date: 2020-01-22, Last modification date: 2024-01-24) |
Primary citation | Tooke, C.L.,Hinchliffe, P.,Krajnc, A.,Mulholland, A.J.,Brem, J.,Schofield, C.J.,Spencer, J. Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition. Rsc Med Chem, 11:491-496, 2020 Cited by PubMed: 33479650DOI: 10.1039/c9md00557a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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