7S0V
The role of an Asp-Asp pair in the structure, function and inhibition of CTX-M Class A Beta-lactamase
Summary for 7S0V
Entry DOI | 10.2210/pdb7s0v/pdb |
Descriptor | Beta-lactamase, 3-(1H-pyrazol-1-yl)-N-[3-(1H-tetrazol-5-yl)phenyl]-5-(trifluoromethyl)benzamide (3 entities in total) |
Functional Keywords | inhibitor, complex, asp-asp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 28398.89 |
Authors | Kemp, M.T.,Chen, Y. (deposition date: 2021-08-31, release date: 2021-11-10, Last modification date: 2024-05-22) |
Primary citation | Kemp, M.T.,Nichols, D.A.,Zhang, X.,Defrees, K.,Na, I.,Renslo, A.R.,Chen, Y. Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A beta-lactamase. Febs Lett., 595:2981-2994, 2021 Cited by PubMed: 34704263DOI: 10.1002/1873-3468.14215 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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