7XAU
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![BU of 7xau by Molmil](/molmil-images/mine/7xau) | Structure of somatostatin receptor 2 bound with octreotide. | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | Deposit date: | 2022-03-19 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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8IW7
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![BU of 8iw7 by Molmil](/molmil-images/mine/8iw7) | Cryo-EM structure of the PEA-bound mTAAR9-Gs complex | Descriptor: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | Deposit date: | 2023-03-29 | Release date: | 2023-05-31 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IHF
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![BU of 8ihf by Molmil](/molmil-images/mine/8ihf) | Cryo-EM structure of HCA2-Gi complex with MK6892 | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8HNL
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![BU of 8hnl by Molmil](/molmil-images/mine/8hnl) | CXCR3-DNGi complex activated by PS372424 | Descriptor: | (3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Jiao, H.Z, Hu, H.L. | Deposit date: | 2022-12-08 | Release date: | 2023-11-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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7VDM
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![BU of 7vdm by Molmil](/molmil-images/mine/7vdm) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Li, Y, Yang, F. | Deposit date: | 2021-09-07 | Release date: | 2021-12-01 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VIH
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![BU of 7vih by Molmil](/molmil-images/mine/7vih) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | Descriptor: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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8JIM
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![BU of 8jim by Molmil](/molmil-images/mine/8jim) | Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex | Descriptor: | (2Z)-4-methoxy-4-oxobut-2-enoic acid, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | Deposit date: | 2023-05-26 | Release date: | 2023-09-06 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol.Cell, 83, 2023
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7EVY
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![BU of 7evy by Molmil](/molmil-images/mine/7evy) | Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | Descriptor: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
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7TUY
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![BU of 7tuy by Molmil](/molmil-images/mine/7tuy) | Cryo-EM structure of GSK682753A-bound EBI2/GPR183 | Descriptor: | 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ... | Authors: | Chen, H, Huang, W, Li, X. | Deposit date: | 2022-02-03 | Release date: | 2022-04-13 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
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8GUT
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![BU of 8gut by Molmil](/molmil-images/mine/8gut) | Cryo-EM structure of LEI-CB2-Gi complex | Descriptor: | 1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Li, X.T, Chang, H, Wu, L.J. | Deposit date: | 2022-09-13 | Release date: | 2023-05-10 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
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8K9K
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![BU of 8k9k by Molmil](/molmil-images/mine/8k9k) | Full agonist-bound mu-type opioid receptor-G protein complex | Descriptor: | DAMGO, G protein subunit alpha i3, Guanine nucleotide binding protein, ... | Authors: | Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. | Deposit date: | 2023-08-01 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator. Nat Commun, 15, 2024
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8HBD
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![BU of 8hbd by Molmil](/molmil-images/mine/8hbd) | Cryo-EM structure of IRL1620-bound ETBR-Gi complex | Descriptor: | Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. | Deposit date: | 2022-10-28 | Release date: | 2023-03-22 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
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7XY6
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![BU of 7xy6 by Molmil](/molmil-images/mine/7xy6) | Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM | Descriptor: | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | Deposit date: | 2022-05-31 | Release date: | 2023-05-03 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
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8GG2
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![BU of 8gg2 by Molmil](/molmil-images/mine/8gg2) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #8 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-08 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFW
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![BU of 8gfw by Molmil](/molmil-images/mine/8gfw) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-08 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFX
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![BU of 8gfx by Molmil](/molmil-images/mine/8gfx) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-08 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8YUV
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![BU of 8yuv by Molmil](/molmil-images/mine/8yuv) | Cryo-EM structure of the immepip-bound H3R-Gi complex | Descriptor: | 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | Deposit date: | 2024-03-27 | Release date: | 2024-06-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
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8GFZ
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![BU of 8gfz by Molmil](/molmil-images/mine/8gfz) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-08 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8HQN
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![BU of 8hqn by Molmil](/molmil-images/mine/8hqn) | Activation mechanism of GPR132 by 9(S)-HODE | Descriptor: | (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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7YFC
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![BU of 7yfc by Molmil](/molmil-images/mine/7yfc) | Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex | Descriptor: | CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Im, D, Iwata, S, Asada, H. | Deposit date: | 2022-07-08 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
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2YDO
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![BU of 2ydo by Molmil](/molmil-images/mine/2ydo) | Thermostabilised HUMAN A2a Receptor with adenosine bound | Descriptor: | ADENOSINE, ADENOSINE RECEPTOR A2A, octyl 1-thio-beta-D-glucopyranoside | Authors: | Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G. | Deposit date: | 2011-03-23 | Release date: | 2011-05-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation. Nature, 474, 2011
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6KP6
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![BU of 6kp6 by Molmil](/molmil-images/mine/6kp6) | The structural study of mutation induced inactivation of Human muscarinic receptor M4 | Descriptor: | Muscarinic acetylcholine receptor M4,GlgA glycogen synthase,Muscarinic acetylcholine receptor M4 | Authors: | Wang, J.J, Wu, M, Wu, L.J, Liu, Z.J, Hua, T. | Deposit date: | 2019-08-14 | Release date: | 2020-03-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structural study of mutation-induced inactivation of human muscarinic receptor M4 Iucrj, 7, 2020
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7CFM
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![BU of 7cfm by Molmil](/molmil-images/mine/7cfm) | Cryo-EM structure of the P395-bound GPBAR-Gs complex | Descriptor: | 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... | Authors: | Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. | Deposit date: | 2020-06-27 | Release date: | 2020-09-09 | Last modified: | 2020-12-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of GPBAR activation and bile acid recognition. Nature, 587, 2020
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7SCG
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![BU of 7scg by Molmil](/molmil-images/mine/7scg) | FH210 bound Mu Opioid Receptor-Gi Protein Complex | Descriptor: | (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, H, Kobilka, B. | Deposit date: | 2021-09-28 | Release date: | 2022-04-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists. Angew.Chem.Int.Ed.Engl., 61, 2022
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6A93
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![BU of 6a93 by Molmil](/molmil-images/mine/6a93) | Crystal structure of 5-HT2AR in complex with risperidone | Descriptor: | 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | Authors: | Kimura, T.K, Asada, H, Inoue, A, Kadji, F.M.N, Im, D, Mori, C, Arakawa, T, Hirata, K, Nomura, Y, Nomura, N, Aoki, J, Iwata, S, Shimamura, T. | Deposit date: | 2018-07-11 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine. Nat.Struct.Mol.Biol., 26, 2019
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