7EVY

Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein

Summary for 7EVY

• Entry DOI: 10.2210/pdb7evy/pdb
• EMDB information: 31341
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: homo sapiens, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 177066.31

Authors

Jia, G.W.,Yuan, Y.,Su, Z.M.,Shao, Z.H. (deposition date: 2021-05-24, release date: 2021-09-29, Last modification date: 2022-02-16)

• Primary citation: Yuan, Y.,Jia, G.,Wu, C.,Wang, W.,Cheng, L.,Li, Q.,Li, Z.,Luo, K.,Yang, S.,Yan, W.,Su, Z.,Shao, Z.; Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.; Cell Res., 31:1263-1274, 2021; PubMed: 34526663; DOI: 10.1038/s41422-021-00566-x

Experimental method

ELECTRON MICROSCOPY (2.98 Å)