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7F83
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Crystal Structure of a receptor in Complex with inverse agonist
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone, Growth hormone secretagogue receptor type 1,Soluble cytochrome b562
Authors:Xu, Z, Shao, Z.
Deposit date:2021-07-01
Release date:2022-01-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular mechanism of agonism and inverse agonism in ghrelin receptor.
Nat Commun, 13, 2022
8IYS
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BU of 8iys by Molmil
TUG891-bound FFAR4 in complex with Gq
Descriptor: 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:He, Y, Yin, H.
Deposit date:2023-04-06
Release date:2023-06-21
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
Cell Res., 33, 2023
5XR8
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BU of 5xr8 by Molmil
Crystal structure of the human CB1 in complex with agonist AM841
Descriptor: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, CHOLESTEROL, Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, ...
Authors:Hua, T, Vemuri, K, Nikas, P.S, Laprairie, R.B, Wu, Y, Qu, L, Pu, M, Korde, A, Shan, J, Ho, J.H, Han, G.W, Ding, K, Li, X, Liu, H, Hanson, M.A, Zhao, S, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J.
Deposit date:2017-06-07
Release date:2017-07-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1.
Nature, 547, 2017
7YON
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BU of 7yon by Molmil
Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kang, H, Park, C, Kim, J, Choi, H.-J.
Deposit date:2022-08-01
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Structure, 31, 2023
8HQM
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BU of 8hqm by Molmil
Activation mechanism of GPR132 by NPGLY
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Wang, J.L, Ding, J.H, Sun, J.P, Yu, X.
Deposit date:2022-12-13
Release date:2023-10-11
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Nat Metab, 5, 2023
5ZKB
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BU of 5zkb by Molmil
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384
Descriptor: Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Authors:Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
2PED
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BU of 2ped by Molmil
Crystallographic model of 9-cis-rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Nakamichi, H, Okada, T.
Deposit date:2007-04-02
Release date:2007-10-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography
Biophys.J., 92, 2007
7W41
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BU of 7w41 by Molmil
Crystal Structure of Human Gastrin Releasing Peptide Receptor in complex with the antagonist PD176252
Descriptor: (2S)-3-(1H-indol-3-yl)-N-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[(4-nitrophenyl)carbamoylamino]propanamide, Gastrin-releasing peptide receptor,GlgA glycogen synthase
Authors:Peng, S, Zhan, Y, Zhang, H.
Deposit date:2021-11-26
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
6MXT
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BU of 6mxt by Molmil
Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Endolysin, ...
Authors:Masureel, M, Zou, Y, Picard, L.P, van der Westhuizen, E, Mahoney, J.P, Rodrigues, J.P.G.L.M, Mildorf, T.J, Dror, R.O, Shaw, D.E, Bouvier, M, Pardon, E, Steyaert, J, Sunahara, R.K, Weis, W.I, Zhang, C, Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95934224 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
7XW5
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BU of 7xw5 by Molmil
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ...
Authors:Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E.
Deposit date:2022-05-26
Release date:2022-08-24
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Hormone- and antibody-mediated activation of the thyrotropin receptor.
Nature, 609, 2022
8KFX
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BU of 8kfx by Molmil
Gi bound CCR8 complex with nonpeptide agonist LMD-009
Descriptor: 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Jiang, S, Lin, X, Wu, L.J, Xu, F.
Deposit date:2023-08-16
Release date:2024-02-07
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024
7S0F
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BU of 7s0f by Molmil
Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein
Descriptor: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y.
Deposit date:2021-08-30
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural basis and mechanism of activation of two different families of G proteins by the same GPCR.
Nat.Struct.Mol.Biol., 28, 2021
8IW7
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BU of 8iw7 by Molmil
Cryo-EM structure of the PEA-bound mTAAR9-Gs complex
Descriptor: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
Deposit date:2023-03-29
Release date:2023-05-31
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
7VV4
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BU of 7vv4 by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local
Descriptor: CHOLESTEROL, Mas-related G-protein coupled receptor member X2, circular cortistatin-14
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VV3
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BU of 7vv3 by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
8GUS
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BU of 8gus by Molmil
Cryo-EM structure of HU-CB2-G protein complex
Descriptor: Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H.
Deposit date:2022-09-13
Release date:2023-05-10
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
7AUE
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BU of 7aue by Molmil
Melanocortin receptor 4 (MC4R) Gs protein complex
Descriptor: AMINOSERINE, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Degtjarik, O, Israeli, H, Prabahar, V, Shalev-Benami, M.
Deposit date:2020-11-02
Release date:2021-04-28
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Science, 372, 2021
8HQE
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BU of 8hqe by Molmil
Cryo-EM structure of the apo-GPR132-Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Wang, J.L, Ding, J.H, Sun, J.P, Yu, X.
Deposit date:2022-12-13
Release date:2023-10-11
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Nat Metab, 5, 2023
8IHF
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BU of 8ihf by Molmil
Cryo-EM structure of HCA2-Gi complex with MK6892
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y.
Deposit date:2023-02-22
Release date:2023-08-30
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
7XAU
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BU of 7xau by Molmil
Structure of somatostatin receptor 2 bound with octreotide.
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L.
Deposit date:2022-03-19
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues.
Cell Discov, 8, 2022
8JIM
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BU of 8jim by Molmil
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
Descriptor: (2Z)-4-methoxy-4-oxobut-2-enoic acid, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
Deposit date:2023-05-26
Release date:2023-09-06
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
7VDM
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BU of 7vdm by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, Y, Yang, F.
Deposit date:2021-09-07
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
8GUT
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BU of 8gut by Molmil
Cryo-EM structure of LEI-CB2-Gi complex
Descriptor: 1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Z.J, Hua, T, Li, X.T, Chang, H, Wu, L.J.
Deposit date:2022-09-13
Release date:2023-05-10
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
8K9K
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BU of 8k9k by Molmil
Full agonist-bound mu-type opioid receptor-G protein complex
Descriptor: DAMGO, G protein subunit alpha i3, Guanine nucleotide binding protein, ...
Authors:Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I.
Deposit date:2023-08-01
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator.
Nat Commun, 15, 2024
7VIH
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BU of 7vih by Molmil
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Descriptor: 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B.
Deposit date:2021-09-26
Release date:2022-09-28
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022

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