8HQE

Cryo-EM structure of the apo-GPR132-Gi

Summary for 8HQE

Entry DOI	10.2210/pdb8hqe/pdb
EMDB information	34948
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, scFv16, ... (5 entities in total)
Functional Keywords	gpcr, gpr132, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	170045.48
Authors	Wang, J.L.,Ding, J.H.,Sun, J.P.,Yu, X. (deposition date: 2022-12-13, release date: 2023-10-11, Last modification date: 2023-11-01)
Primary citation	Wang, J.L.,Dou, X.D.,Cheng, J.,Gao, M.X.,Xu, G.F.,Ding, W.,Ding, J.H.,Li, Y.,Wang, S.H.,Ji, Z.W.,Zhao, X.Y.,Huo, T.Y.,Zhang, C.F.,Liu, Y.M.,Sha, X.Y.,Gao, J.R.,Zhang, W.H.,Hao, Y.,Zhang, C.,Sun, J.P.,Jiao, N.,Yu, X. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5:1726-1746, 2023 Cited by PubMed: 37770763 DOI: 10.1038/s42255-023-00899-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.97 Å)

Structure validation