7W41

Crystal Structure of Human Gastrin Releasing Peptide Receptor in complex with the antagonist PD176252

Summary for 7W41

• Entry DOI: 10.2210/pdb7w41/pdb
• Descriptor: Gastrin-releasing peptide receptor,GlgA glycogen synthase, (2S)-3-(1H-indol-3-yl)-N-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[(4-nitrophenyl)carbamoylamino]propanamide (2 entities in total)
• Functional Keywords: gpcr, gastrin releasing peptide receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 54959.42

Authors

Peng, S.,Zhan, Y.,Zhang, H. (deposition date: 2021-11-26, release date: 2023-02-22, Last modification date: 2023-11-29)

• Primary citation: Peng, S.,Zhan, Y.,Zhang, D.,Ren, L.,Chen, A.,Chen, Z.F.,Zhang, H.; Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.; Proc.Natl.Acad.Sci.USA, 120:e2216230120-e2216230120, 2023; PubMed: 36724251; DOI: 10.1073/pnas.2216230120

Experimental method

X-RAY DIFFRACTION (2.952 Å)