7W41

Crystal Structure of Human Gastrin Releasing Peptide Receptor in complex with the antagonist PD176252

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Gastrin-releasing peptide receptor,GlgA glycogen synthase	polymer	484	54374.8	1	UniProt (P30550) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692)	Homo sapiens (human)	GRP-R,GRP-preferring bombesin receptor,Glycogen synthase
2	B (A)	(2S)-3-(1H-indol-3-yl)-N-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[(4-nitrophenyl)carbamoylamino]propanamide	non-polymer		584.7	1	Chemie (8B8)

Sequence modifications

A: 38 - 241 (UniProt: P30550)

PDB	External Database	Details
Lys 127	Ser 127	engineered mutation
Ala 157	Ile 157	engineered mutation

A: 242 - 437 (UniProt: Q9V2J8)
A: 438 - 521 (UniProt: P30550)

PDB	External Database	Details
Glu 443	Arg 259	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54374.8
Non-Polymers*	Number of molecules	1
	Total formula weight	584.7
All*	Total formula weight	54959.4

*Water molecules are not included.