8GRM
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![BU of 8grm by Molmil](/molmil-images/mine/8grm) | Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome | Descriptor: | COMMD3 protein, DNA (144-MER), DNA (145-MER), ... | Authors: | Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | Deposit date: | 2022-09-02 | Release date: | 2023-04-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
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8G9B
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![BU of 8g9b by Molmil](/molmil-images/mine/8g9b) | Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | Authors: | O'Neill, A.G, Kollman, J.M. | Deposit date: | 2023-02-21 | Release date: | 2023-04-19 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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8FCO
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![BU of 8fco by Molmil](/molmil-images/mine/8fco) | Cryo-EM structure of p97:UBXD1 meta state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 | Authors: | Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. | Deposit date: | 2022-12-01 | Release date: | 2023-06-21 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
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8G16
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![BU of 8g16 by Molmil](/molmil-images/mine/8g16) | |
8G17
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![BU of 8g17 by Molmil](/molmil-images/mine/8g17) | CryoEM structure of wild-type GAPDH | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase | Authors: | Choi, W.Y, Wu, H, Cheng, Y.F. | Deposit date: | 2023-02-01 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (1.98 Å) | Cite: | Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM. Proc.Natl.Acad.Sci.USA, 120, 2023
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8G15
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![BU of 8g15 by Molmil](/molmil-images/mine/8g15) | |
8H3H
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![BU of 8h3h by Molmil](/molmil-images/mine/8h3h) | Human ATAD2 Walker B mutant, ATP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | Authors: | Cho, C, Song, J. | Deposit date: | 2022-10-08 | Release date: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication. Commun Biol, 6, 2023
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8HQ6
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![BU of 8hq6 by Molmil](/molmil-images/mine/8hq6) | KL2 in complex with CRM1-Ran-RanBP1 | Descriptor: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | Authors: | Sun, Q, Jian, L. | Deposit date: | 2022-12-13 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8HQ3
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![BU of 8hq3 by Molmil](/molmil-images/mine/8hq3) | KL1 in complex with CRM1-Ran-RanBP1 | Descriptor: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | Authors: | Sun, Q, Jian, L. | Deposit date: | 2022-12-13 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8H9Z
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![BU of 8h9z by Molmil](/molmil-images/mine/8h9z) | Annexin A5 protein mutant | Descriptor: | Annexin A5, CALCIUM ION | Authors: | Hua, Z.C, Tang, W. | Deposit date: | 2022-10-26 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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8HR1
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![BU of 8hr1 by Molmil](/molmil-images/mine/8hr1) | Cryo-EM structure of SSX1 bound to the unmodified nucleosome at a resolution of 3.02 angstrom | Descriptor: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | Zebin, T, Ai, H.S, Ziyu, X, Man, P, Liu, L. | Deposit date: | 2022-12-14 | Release date: | 2023-09-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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8H0J
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![BU of 8h0j by Molmil](/molmil-images/mine/8h0j) | Annexin A5 mutant | Descriptor: | Annexin A5, CALCIUM ION | Authors: | Hua, Z.C, Tang, W. | Deposit date: | 2022-09-29 | Release date: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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8HQY
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![BU of 8hqy by Molmil](/molmil-images/mine/8hqy) | Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | Descriptor: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | Authors: | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | Deposit date: | 2022-12-14 | Release date: | 2023-09-27 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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8HLW
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![BU of 8hlw by Molmil](/molmil-images/mine/8hlw) | Crystal structure of SIRT3 in complex with H4K16la peptide | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, Histone H4 residues 20-27, NAD-dependent protein deacetylase sirtuin-3, ... | Authors: | Zhuming, F, Hao, Q. | Deposit date: | 2022-12-01 | Release date: | 2023-09-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of SIRT3 as an eraser of H4K16la. Iscience, 26, 2023
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8G1U
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![BU of 8g1u by Molmil](/molmil-images/mine/8g1u) | Structure of the methylosome-Lsm10/11 complex | Descriptor: | ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... | Authors: | Lin, M, Paige, A, Tong, L. | Deposit date: | 2023-02-03 | Release date: | 2023-08-23 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
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8HE7
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![BU of 8he7 by Molmil](/molmil-images/mine/8he7) | ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor | Descriptor: | 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | Deposit date: | 2022-11-07 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J.Med.Chem., 66, 2023
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8HQ4
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![BU of 8hq4 by Molmil](/molmil-images/mine/8hq4) | B27 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Lei, Y, Sun, Q. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | B27 in complex with CRM1-Ran-RanBP1 To Be Published
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8HQ5
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![BU of 8hq5 by Molmil](/molmil-images/mine/8hq5) | G6 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | F1 in complex with CRM1-Ran-RanBP1 To Be Published
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8HUG
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![BU of 8hug by Molmil](/molmil-images/mine/8hug) | F1 in complex with CRM1-Ran-RanBP1 | Descriptor: | 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-23 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8HUF
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![BU of 8huf by Molmil](/molmil-images/mine/8huf) | B28 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-23 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8G13
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![BU of 8g13 by Molmil](/molmil-images/mine/8g13) | |
8G12
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![BU of 8g12 by Molmil](/molmil-images/mine/8g12) | |
8G14
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![BU of 8g14 by Molmil](/molmil-images/mine/8g14) | |
8FTA
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![BU of 8fta by Molmil](/molmil-images/mine/8fta) | |
8FW6
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![BU of 8fw6 by Molmil](/molmil-images/mine/8fw6) | Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336 | Descriptor: | (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | Authors: | Lowther, W.T, Gumpena, R. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Human Lactate Dehydrogenase A in complex with inhibitor CHK-336 To Be Published
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