8HUF

B28 in complex with CRM1-Ran-RanBP1

Summary for 8HUF

• Entry DOI: 10.2210/pdb8huf/pdb
• Descriptor: GTP-binding nuclear protein Ran, 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, YRB1 isoform 1, ... (11 entities in total)
• Functional Keywords: nuclear export inhibitor, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 157370.27

Authors

Sun, Q.,Lei, Y. (deposition date: 2022-12-23, release date: 2023-12-27, Last modification date: 2024-07-10)

• Primary citation: Li, C.,Zhang, Q.,Huang, W.,Huang, L.,Long, Q.,Lei, Y.,Jia, D.,Yang, S.,Yang, Y.,Zhang, X.,Sun, Q.; Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors.; J.Med.Chem., 66:17044-17058, 2023; PubMed: 38105606; DOI: 10.1021/acs.jmedchem.3c01867

Experimental method

X-RAY DIFFRACTION (2.29 Å)