8G9B

Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction

Summary for 8G9B

Entry DOI	10.2210/pdb8g9b/pdb
EMDB information	29357 29482 29848 29863
Descriptor	Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	filament, dehydrogenase, cbs domain, bateman domain, purine biosynthesis, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	472237.00
Authors	O'Neill, A.G.,Kollman, J.M. (deposition date: 2023-02-21, release date: 2023-04-19, Last modification date: 2023-08-09)
Primary citation	O'Neill, A.G.,Burrell, A.L.,Zech, M.,Elpeleg, O.,Harel, T.,Edvardson, S.,Mor-Shaked, H.,Rippert, A.L.,Nomakuchi, T.,Izumi, K.,Kollman, J.M. Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299:105012-105012, 2023 Cited by PubMed: 37414152 DOI: 10.1016/j.jbc.2023.105012 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation