6R7I
| Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | Descriptor: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | Authors: | Faull, S.F, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A. | Deposit date: | 2019-03-28 | Release date: | 2019-08-28 | Last modified: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
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6R6H
| Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | Descriptor: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | Authors: | Morris, E.P, Faull, S.V, Lau, A.M.C, Politis, A, Beuron, F, Cronin, N. | Deposit date: | 2019-03-27 | Release date: | 2019-08-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (8.4 Å) | Cite: | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
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6TNT
| SUMOylated apoAPC/C with repositioned APC2 WHB domain | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Barford, D, Yatskevich, S. | Deposit date: | 2019-12-10 | Release date: | 2021-01-13 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation. Cell Rep, 34, 2021
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6TM5
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8KHP
| CULLIN3-KLHL22-RBX1 E3 ligase | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22 | Authors: | Su, M.-Y, Su, M.-Y. | Deposit date: | 2023-08-22 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure, 31, 2023
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7Z8B
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8K8T
| Structure of CUL3-RBX1-KLHL22 complex | Descriptor: | Cullin-3, Kelch-like protein 22 | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-07-31 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
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8K9I
| Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-08-01 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
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8PKP
| Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2023-06-27 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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8PQL
| K48-linked ubiquitin chain formation with a cullin-RING E3 ligase and Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2-donor UB-acceptor UB-SIL1 peptide | Descriptor: | 5-azanylpentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | Deposit date: | 2023-07-11 | Release date: | 2024-02-14 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nat.Struct.Mol.Biol., 31, 2024
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8A5Y
| S. cerevisiae apo unphosphorylated APC/C. | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... | Authors: | Barford, D, Fernandez-Vazquez, E, Zhang, Z, Yang, J. | Deposit date: | 2022-06-16 | Release date: | 2022-08-31 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex and comparison to apo unphosphorylated and phosphorylated states To Be Published
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8A61
| S. cerevisiae apo phosphorylated APC/C | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... | Authors: | Barford, D, Fernandez-Vazquez, E, Zhang, Z, Yang, J. | Deposit date: | 2022-06-16 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Cryo-EM structure of the S. cerevisiae apo phosphorylated APC/C To Be Published
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8A3T
| S. cerevisiae APC/C-Cdh1 complex | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... | Authors: | Barford, D, Vazquez-Fernandez, E, Zhang, Z, Yang, J. | Deposit date: | 2022-06-09 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex To Be Published
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8Q7R
| Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide | Descriptor: | 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | Deposit date: | 2023-08-16 | Release date: | 2024-02-21 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
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8Q7H
| Structure of CUL9-RBX1 ubiquitin E3 ligase complex in unneddylated and neddylated conformation - focused cullin dimer | Descriptor: | Cullin-9, E3 ubiquitin-protein ligase RBX1, NEDD8, ... | Authors: | Hopf, L.V.M, Horn-Ghetko, D, Schulman, B.A. | Deposit date: | 2023-08-16 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nat.Struct.Mol.Biol., 2024
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8QU8
| PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 | Descriptor: | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Fischer, G, Peter, D, Arce-Solano, S. | Deposit date: | 2023-10-14 | Release date: | 2023-12-06 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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8R5H
| Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-VHL-MZ1 with trapped UBE2R2~donor UB-BRD4 BD2 | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 5-azanylpentan-2-one, Bromodomain-containing protein 4, ... | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | Deposit date: | 2023-11-16 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
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8B3I
| CRL4CSA-E2-Ub (state 2) | Descriptor: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2022-09-16 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | C(N)RL4CSA-E2-Ub (state 2) To Be Published
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8TAR
| APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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8TAU
| APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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8U81
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U82
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U83
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.975 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U84
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State D From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WQF
| cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | Authors: | Chen, X, Zhang, K, Xu, C. | Deposit date: | 2023-10-11 | Release date: | 2024-04-03 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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