8Q7R

Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide

Summary for 8Q7R

Entry DOI	10.2210/pdb8q7r/pdb
EMDB information	18207 18230
Descriptor	Cullin-2, ZINC ION, Protein fem-1 homolog C, ... (10 entities in total)
Functional Keywords	cul2, fem1c, elobc, sil1, ubiquitin, ubiquitin ligase, ubiquitylation, monoubiquitylation, ligase, elongin b, elongin c
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	300667.34
Authors	Liwocha, J.,Prabu, J.R.,Kleiger, G.,Schulman, B.A. (deposition date: 2023-08-16, release date: 2024-02-21, Last modification date: 2024-04-24)
Primary citation	Li, J.,Purser, N.,Liwocha, J.,Scott, D.C.,Byers, H.A.,Steigenberger, B.,Hill, S.,Tripathi-Giesgen, I.,Hinkle, T.,Hansen, F.M.,Prabu, J.R.,Radhakrishnan, S.K.,Kirkpatrick, D.S.,Reichermeier, K.M.,Schulman, B.A.,Kleiger, G. Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84:1304-, 2024 Cited by PubMed: 38382526 DOI: 10.1016/j.molcel.2024.01.022 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.71 Å)

Structure validation