8QU8
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Summary for 8QU8
Entry DOI | 10.2210/pdb8qu8/pdb |
EMDB information | 18657 |
Descriptor | von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (9 entities in total) |
Functional Keywords | targeted protein degradation, protac, gtpase, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 169494.67 |
Authors | Fischer, G.,Peter, D.,Arce-Solano, S. (deposition date: 2023-10-14, release date: 2023-12-06, Last modification date: 2024-01-24) |
Primary citation | Popow, J.,Farnaby, W.,Gollner, A.,Kofink, C.,Fischer, G.,Wurm, M.,Zollman, D.,Wijaya, A.,Mischerikow, N.,Hasenoehrl, C.,Prokofeva, P.,Arnhof, H.,Arce-Solano, S.,Bell, S.,Boeck, G.,Diers, E.,Frost, A.,Goodwin-Tindall, J.,Karolyi-Oezguer, J.,Khan, S.,Klawatsch, T.,Koegl, M.,Kousek, R.,Kratochvil, B.,Kropatsch, K.,Lauber, A.,McLennan, R.,Olt, S.,Peter, D.,Petermann, O.,Roessler, V.,Stolt-Bergner, P.,Strack, P.,Strauss, E.,Trainor, N.,Vetma, V.,Whitworth, C.,Zhong, S.,Quant, J.,Weinstabl, H.,Kuster, B.,Ettmayer, P.,Ciulli, A. Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023 Cited by DOI: 10.1101/2023.10.24.563163PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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