8QU8
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | von Hippel-Lindau disease tumor suppressor | polymer | 212 | 24049.5 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB | Homo sapiens (human) | |
| 2 | B | Elongin-B | polymer | 117 | 13016.6 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C | Elongin-C | polymer | 111 | 12353.9 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D | Cullin-2 | polymer | 744 | 86967.7 | 1 | UniProt (Q13617) Pfam (PF00888) Pfam (PF10557) In PDB | Homo sapiens (human) | CUL-2 |
| 5 | E | E3 ubiquitin-protein ligase RBX1, N-terminally processed | polymer | 107 | 12158.8 | 1 | UniProt (P62877) Pfam (PF12678) In PDB | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,N-terminally processed |
| 6 | F | GTPase KRas | polymer | 170 | 19354.8 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 7 | E | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 8 | F | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 9 | F | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 1019.2 | 1 | Chemie (WYL) |
Sequence modifications
F: 1 - 164 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Gly 151 | Arg 151 | variant |
| Asp 153 | Glu 153 | variant |
| Lys 165 | - | expression tag |
| His 166 | - | expression tag |
| Lys 167 | - | expression tag |
| Glu 168 | - | expression tag |
| Lys 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 167901.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1593.3 | |
| All* | Total formula weight | 169494.7 |
