8PQL

K48-linked ubiquitin chain formation with a cullin-RING E3 ligase and Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2-donor UB-acceptor UB-SIL1 peptide

Summary for 8PQL

Entry DOI	10.2210/pdb8pql/pdb
EMDB information	17798 17799 17800 17801 17802 17803 17822
Descriptor	Ubiquitin-conjugating enzyme E2 R2, ZINC ION, Polyubiquitin-C,Nucleotide exchange factor SIL1, ... (10 entities in total)
Functional Keywords	cul2, fem1c, elobc, sil1, ubiquitin, ubiquitin ligase, ubiquitin chain formation, poliubiquitylation, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	377624.55
Authors	Liwocha, J.,Prabu, J.R.,Kleiger, G.,Schulman, B.A. (deposition date: 2023-07-11, release date: 2024-02-14, Last modification date: 2024-04-17)
Primary citation	Liwocha, J.,Li, J.,Purser, N.,Rattanasopa, C.,Maiwald, S.,Krist, D.T.,Scott, D.C.,Steigenberger, B.,Prabu, J.R.,Schulman, B.A.,Kleiger, G. Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nat.Struct.Mol.Biol., 31:378-389, 2024 Cited by PubMed: 38326650 DOI: 10.1038/s41594-023-01206-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.76 Å)

Structure validation