8TAU

APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB

Summary for 8TAU

Entry DOI	10.2210/pdb8tau/pdb
EMDB information	41142
Descriptor	Anaphase-promoting complex subunit 1, Cell division cycle protein 16 homolog, Anaphase-promoting complex subunit 10, ... (19 entities in total)
Functional Keywords	e3 ring ligase, ubiquitin ligase, apc/c, anaphase-promoting complex-cyclosome, cell cycle, cullin-ring ligase, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	23
Total formula weight	1239324.22
Authors	Bodrug, T.,Welsh, K.A.,Bolhuis, D.L.,Paulakonis, E.,Martinez-Chacin, R.C.,Liu, B.,Pinkin, N.,Bonacci, T.,Cui, L.,Xu, P.,Roscow, O.,Amann, S.J.,Grishkovskaya, I.,Emanuele, M.J.,Harrison, J.S.,Steimel, J.P.,Hahn, K.M.,Zhang, W.,Zhong, E.,Haselbach, D.,Brown, N.G. (deposition date: 2023-06-27, release date: 2023-09-27, Last modification date: 2023-12-13)
Primary citation	Bodrug, T.,Welsh, K.A.,Bolhuis, D.L.,Paulakonis, E.,Martinez-Chacin, R.C.,Liu, B.,Pinkin, N.,Bonacci, T.,Cui, L.,Xu, P.,Roscow, O.,Amann, S.J.,Grishkovskaya, I.,Emanuele, M.J.,Harrison, J.S.,Steimel, J.P.,Hahn, K.M.,Zhang, W.,Zhong, E.D.,Haselbach, D.,Brown, N.G. Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30:1663-1674, 2023 Cited by PubMed: 37735619 DOI: 10.1038/s41594-023-01105-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation