6XKK
| Cryo-EM structure of the NLRP1-CARD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 1 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | Deposit date: | 2020-06-26 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
|
|
6XKJ
| Cryo-EM structure of CARD8-CARD filament | Descriptor: | Caspase recruitment domain-containing protein 8 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | Deposit date: | 2020-06-26 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
|
|
7KEU
| Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, Caspase-1 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H. | Deposit date: | 2020-10-12 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
|
|
6X6C
| Cryo-EM structure of NLRP1-DPP9-VbP complex | Descriptor: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | Deposit date: | 2020-05-27 | Release date: | 2021-03-10 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
|
|
6X6A
| Cryo-EM structure of NLRP1-DPP9 complex | Descriptor: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1 | Authors: | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | Deposit date: | 2020-05-27 | Release date: | 2021-03-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
|
|
4PX9
| DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
|
|
4PXA
| DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
|
|
8WCM
| |
8K8T
| Structure of CUL3-RBX1-KLHL22 complex | Descriptor: | Cullin-3, Kelch-like protein 22 | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-07-31 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
|
|
8K9I
| Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-08-01 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
|
|
2MAI
| NMR structure of lassomycin | Descriptor: | Lassomycin | Authors: | Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K. | Deposit date: | 2013-07-09 | Release date: | 2014-05-07 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. Chem.Biol., 21, 2014
|
|
4XJJ
| |
4WMY
| |
4WMQ
| |
4XGK
| Crystal structure of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, UDP-galactopyranose mutase, ... | Authors: | Wangkanont, K, Heroux, A, Forest, K.T, Kiessling, L.L. | Deposit date: | 2014-12-31 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.652 Å) | Cite: | Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. Acs Chem.Biol., 10, 2015
|
|
4WMO
| |
4WN0
| Xenopus laevis embryonic epidermal lectin in complex with glycerol phosphate | Descriptor: | CALCIUM ION, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | Authors: | Wangkanont, K, Kiessling, L.L, Forest, K.T. | Deposit date: | 2014-10-10 | Release date: | 2016-01-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition. J.Biol.Chem., 291, 2016
|
|
4XAD
| |
8E1X
| FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) | Descriptor: | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2 | Authors: | Lei, H.-T, Epling, L.B, Deller, M.C. | Deposit date: | 2022-08-11 | Release date: | 2022-11-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3. J.Med.Chem., 65, 2022
|
|
3KYB
| |
2LGI
| Atomic Resolution Protein Structures using NMR Chemical Shift Tensors | Descriptor: | Immunoglobulin G-binding protein G | Authors: | Wylie, B.J, Sperling, L.J, Nieuwkoop, A.J, Franks, W.T, Oldfield, E, Rienstra, C.M. | Deposit date: | 2011-07-26 | Release date: | 2011-10-26 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Ultrahigh resolution protein structures using NMR chemical shift tensors. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
2LEG
| Membrane protein complex DsbB-DsbA structure by joint calculations with solid-state NMR and X-ray experimental data | Descriptor: | Disulfide bond formation protein B, Thiol:disulfide interchange protein DsbA, UBIQUINONE-1, ... | Authors: | Tang, M, Sperling, L.J, Berthold, D.A, Schwieters, C.D, Nesbitt, A.E, Nieuwkoop, A.J, Gennis, R.B, Rienstra, C.M. | Deposit date: | 2011-06-15 | Release date: | 2011-10-26 | Last modified: | 2023-06-14 | Method: | SOLID-STATE NMR | Cite: | High-resolution membrane protein structure by joint calculations with solid-state NMR and X-ray experimental data. J.Biomol.Nmr, 51, 2011
|
|
3MMJ
| Structure of the PTP-like phytase from Selenomonas ruminantium in complex with myo-inositol hexakisphosphate | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Gruninger, R.J, Selinger, L.B, Mosimann, S.C. | Deposit date: | 2010-04-20 | Release date: | 2011-06-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Substrate binding in protein-tyrosine phosphatase-like inositol polyphosphatases. J.Biol.Chem., 287, 2012
|
|
3MOZ
| Structure of the PTP-like phytase from Selenomonas ruminantium in complex with myo-inositol (1,2,3,5,6)pentakisphosphate | Descriptor: | (1R,2R,3R,4R,5S,6S)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)], ACETATE ION, CHLORIDE ION, ... | Authors: | Gruninger, R.J, Selinger, L.B, Mosimann, S.C. | Deposit date: | 2010-04-23 | Release date: | 2011-06-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Substrate binding in protein-tyrosine phosphatase-like inositol polyphosphatases. J.Biol.Chem., 287, 2012
|
|
6XTU
| FULL-LENGTH LTTR LYSG FROM CORYNEBACTERIUM GLUTAMICUM | Descriptor: | Lysine export transcriptional regulatory protein LysG | Authors: | Hofmann, E, Syberg, F, Schlicker, C, Eggeling, L, Schendzielorz, G. | Deposit date: | 2020-01-16 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Engineering and application of a biosensor with focused ligand specificity. Nat Commun, 11, 2020
|
|