6I9J
| Human transforming growth factor beta2 in a tetragonal crystal form | Descriptor: | Transforming growth factor beta-2 proprotein | Authors: | Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. | Deposit date: | 2018-11-23 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation. Sci Rep, 9, 2019
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7L0J
| Structure of AMH bound to AMHR2-ECD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ... | Authors: | Hart, K.N, Thompson, T.B. | Deposit date: | 2020-12-11 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family. Proc.Natl.Acad.Sci.USA, 118, 2021
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8V52
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7RCO
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5E4G
| Crystal structure of human growth differentiation factor 11 (GDF-11) | Descriptor: | Growth/differentiation factor 11, TETRAETHYLENE GLYCOL | Authors: | Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A. | Deposit date: | 2015-10-06 | Release date: | 2016-03-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of human GDF11. Acta Crystallogr.,Sect.F, 72, 2016
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4KV5
| scFv GC1009 in complex with TGF-beta1. | Descriptor: | Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein | Authors: | Wei, R, Moulin, A.G, Mathieu, M. | Deposit date: | 2013-05-22 | Release date: | 2014-09-24 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23, 2014
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2TGI
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1ZKZ
| Crystal Structure of BMP9 | Descriptor: | Growth/differentiation factor 2 | Authors: | Brown, M.A, Zhao, Q, Baker, K.A, Naik, C, Chen, C, Pukac, L, Singh, M, Tsareva, T, Parice, Y, Mahoney, A, Roschke, V, Sanyal, I, Choe, S. | Deposit date: | 2005-05-04 | Release date: | 2005-05-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Crystal structure of BMP-9 and functional interactions with pro-region and receptors J.Biol.Chem., 280, 2005
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5JI1
| Crystal Structure of GDF8 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Growth/differentiation factor 8 | Authors: | Walker, R.G, Thompson, T.B. | Deposit date: | 2016-04-21 | Release date: | 2017-03-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for potency differences between GDF8 and GDF11. BMC Biol., 15, 2017
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1BMP
| BONE MORPHOGENETIC PROTEIN-7 | Descriptor: | BONE MORPHOGENETIC PROTEIN-7 | Authors: | Griffith, D.L, Scott, D.L. | Deposit date: | 1995-12-14 | Release date: | 1997-07-23 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. Proc.Natl.Acad.Sci.USA, 93, 1996
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1AGQ
| GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT | Descriptor: | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR | Authors: | Eigenbrot, C, Gerber, N. | Deposit date: | 1997-03-25 | Release date: | 1997-06-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat.Struct.Biol., 4, 1997
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2ARV
| Structure of human Activin A | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, GLYCEROL, Inhibin beta A chain, ... | Authors: | Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M. | Deposit date: | 2005-08-22 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the inhibition of activin signalling by follistatin Embo J., 25, 2006
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2QCW
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2R53
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2R52
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6SF3
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6SF1
| Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1). | Descriptor: | Bone morphogenetic protein 10, NICKEL (II) ION, Serine/threonine-protein kinase receptor R3 | Authors: | Salmon, R.M, Guo, J, Yu, M, Li, W. | Deposit date: | 2019-07-30 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
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7ZJF
| R399E, a mutated form of GDF5, for disease modification of osteoarthritis | Descriptor: | Growth/differentiation factor 5 | Authors: | Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K. | Deposit date: | 2022-04-10 | Release date: | 2022-09-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis. Arthritis Rheumatol, 75, 2023
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3BMP
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3BK3
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4MID
| Crystal Structure of Activin A/BMP2 chimera | Descriptor: | AB204 Activin A/BMP2 chimera | Authors: | Esquivies, L. | Deposit date: | 2013-08-30 | Release date: | 2014-05-07 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.139 Å) | Cite: | An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2. J.Bone Miner.Res., 29, 2014
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4MPL
| Crystal structure of BMP9 at 1.90 Angstrom | Descriptor: | Growth/differentiation factor 2 | Authors: | Li, W, Morrell, N.W, Wei, Z. | Deposit date: | 2013-09-13 | Release date: | 2014-09-17 | Last modified: | 2021-06-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis. J.Biol.Chem., 289, 2014
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2BHK
| Crystal structure of human growth and differentiation factor 5 (GDF5) | Descriptor: | GROWTH DIFFERENTIATION FACTOR 5, ISOPROPYL ALCOHOL | Authors: | Schreuder, H, Liesum, A, Pohl, J, Kruse, M, Koyama, M. | Deposit date: | 2005-01-12 | Release date: | 2005-03-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of Recombinant Human Growth Differentiation Factor 5. Evidence for Interaction of the Type I and Type II Receptor Binding Sites. Biochem.Biophys.Res.Commun., 329, 2005
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8E3G
| BMP2/GDF5 heterodimer | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 | Authors: | Gipson, G.R, Nolan, K.T, Thompson, T.B. | Deposit date: | 2022-08-17 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers. Bmc Biol., 21, 2023
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4KXZ
| crystal structure of tgfb2 in complex with GC2008. | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ... | Authors: | Mathieu, M, Moulin, A.G, Wei, R. | Deposit date: | 2013-05-28 | Release date: | 2014-09-24 | Last modified: | 2014-12-03 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23, 2014
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