8E3G

BMP2/GDF5 heterodimer

Summary for 8E3G

Entry DOI	10.2210/pdb8e3g/pdb
Descriptor	Bone morphogenetic protein 2, Growth/differentiation factor 5, GLYCEROL (3 entities in total)
Functional Keywords	cystine-knot growth factor heterodimer, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	53505.45
Authors	Gipson, G.R.,Nolan, K.T.,Thompson, T.B. (deposition date: 2022-08-17, release date: 2023-02-15, Last modification date: 2024-11-06)
Primary citation	Gipson, G.R.,Nolan, K.,Kattamuri, C.,Kenny, A.P.,Agricola, Z.,Edwards, N.A.,Zinski, J.,Czepnik, M.,Mullins, M.C.,Zorn, A.M.,Thompson, T.B. Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers. Bmc Biol., 21:16-16, 2023 Cited by PubMed Abstract: Proteins of the TGFβ family, which are largely studied as homodimers, are also known to form heterodimers with biological activity distinct from their component homodimers. For instance, heterodimers of bone morphogenetic proteins, including BMP2/BMP7, BMP2/BMP6, and BMP9/BMP10, among others, have illustrated the importance of these heterodimeric proteins within the context of TGFβ signaling. PubMed: 36726183 DOI: 10.1186/s12915-023-01522-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation