4KXZ

crystal structure of tgfb2 in complex with GC2008.

Summary for 4KXZ

• Entry DOI: 10.2210/pdb4kxz/pdb
• Related: 3EO0 3EO1 4KV5
• Descriptor: Transforming growth factor beta-2, GC1008 Heavy Chain, GC1008 Light Chain, ... (6 entities in total)
• Functional Keywords: cysteine knot, fab, various growth functions (tgf-beta), tgf-beta antagonist (gc2008), tgf-beta receptors, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P61812
• Total number of polymer chains: 12
• Total formula weight: 241640.13

Authors

Mathieu, M.,Moulin, A.G.,Wei, R. (deposition date: 2013-05-28, release date: 2014-09-24, Last modification date: 2014-12-03)

• Primary citation: Moulin, A.,Mathieu, M.,Lawrence, C.,Bigelow, R.,Levine, M.,Hamel, C.,Marquette, J.P.,Le Parc, J.,Loux, C.,Ferrari, P.,Capdevila, C.,Dumas, J.,Dumas, B.,Rak, A.,Bird, J.,Qiu, H.,Pan, C.Q.,Edmunds, T.,Wei, R.R.; Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.; Protein Sci., 23:1698-1707, 2014; PubMed: 25209176; DOI: 10.1002/pro.2548

Experimental method

X-RAY DIFFRACTION (2.83 Å)