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4KXZ

crystal structure of tgfb2 in complex with GC2008.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008083molecular_functiongrowth factor activity
B0005576cellular_componentextracellular region
B0008083molecular_functiongrowth factor activity
D0005576cellular_componentextracellular region
D0008083molecular_functiongrowth factor activity
E0005576cellular_componentextracellular region
E0008083molecular_functiongrowth factor activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MES A 201
ChainResidue
AILE98
AGLU99
AGLN100
NLYS13
NPRO14
NGLY15

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MES E 201
ChainResidue
HPRO14
HGLY15
HSER120
EGLU99
EGLN100
HLYS13

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MES J 301
ChainResidue
JASN162
JSER163
JTHR202
JASN204
PVAL151
PGLN156
PLEU182
PASP186
PHIS190

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MES Q 801
ChainResidue
IVAL151
IGLN156
ILEU182
IASP186
IHIS190
QASN162
QSER163
QTHR202
QASN204
QASP215

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MES M 301
ChainResidue
MGLY9
MVAL86
MGLY102
MARG104
MTHR198
MHIS199
MGLN200
MHOH431

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PE5 P 701
ChainResidue
DTYR91
DGLY93
DLYS94
PSER28
PLEU29
PTYR33
PALA93

Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYnanfCaGaC
ChainResidueDetails
AILE33-CYS48

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
ITYR193-HIS199
HTYR201-HIS207

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PDB entries from 2024-11-06

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