Crystal Structure of Activin A/BMP2 chimera

Summary for 4MID

DescriptorAB204 Activin A/BMP2 chimera (2 entities in total)
Functional Keywordscysteine knot, cytokine, actrii, bmpria, secreted
Biological sourceHomo sapiens
Total number of polymer chains1
Total molecular weight13090.08
Esquivies, L. (deposition date: 2013-08-30, release date: 2014-05-07, Last modification date: 2019-07-17)
Primary citation
Yoon, B.H.,Esquivies, L.,Ahn, C.,Gray, P.C.,Ye, S.K.,Kwiatkowski, W.,Choe, S.
An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2.
J.Bone Miner.Res., 29:1950-1959, 2014
PubMed: 24692083 (PDB entries with the same primary citation)
DOI: 10.1002/jbmr.2238
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.278110 3.2% 9.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02