4KV5
scFv GC1009 in complex with TGF-beta1.
Summary for 4KV5
Entry DOI | 10.2210/pdb4kv5/pdb |
Related | 3EO0 3EO1 4KXZ |
Descriptor | Transforming growth factor beta-1 proprotein, Single-chain variable fragment GC1009 (2 entities in total) |
Functional Keywords | cysteine knot, fab, tgf-beta receptor mimetic, tgf-beta, tgf-beta receptor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 157865.60 |
Authors | Wei, R.,Moulin, A.G.,Mathieu, M. (deposition date: 2013-05-22, release date: 2014-09-24, Last modification date: 2019-12-25) |
Primary citation | Moulin, A.,Mathieu, M.,Lawrence, C.,Bigelow, R.,Levine, M.,Hamel, C.,Marquette, J.P.,Le Parc, J.,Loux, C.,Ferrari, P.,Capdevila, C.,Dumas, J.,Dumas, B.,Rak, A.,Bird, J.,Qiu, H.,Pan, C.Q.,Edmunds, T.,Wei, R.R. Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23:1698-1707, 2014 Cited by PubMed: 25209176DOI: 10.1002/pro.2548 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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