7RCO
Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab
Summary for 7RCO
Entry DOI | 10.2210/pdb7rco/pdb |
Descriptor | Transforming growth factor beta-2, 4A11.V2 Fab Light Chain, 4A11.V2 Fab Heavy Chain, ... (4 entities in total) |
Functional Keywords | tgf-beta-2, conformational antibody, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 121379.65 |
Authors | Yin, J.,Lupardus, P.J.,Sudhamsu, J. (deposition date: 2021-07-07, release date: 2021-09-29, Last modification date: 2023-10-18) |
Primary citation | Liang, W.C.,Yin, J.,Lupardus, P.,Zhang, J.,Loyet, K.M.,Sudhamsu, J.,Wu, Y. Dramatic activation of an antibody by a single amino acid change in framework. Sci Rep, 11:22365-22365, 2021 Cited by PubMed: 34785671DOI: 10.1038/s41598-021-01530-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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